CAJ | 학술논문

目的观察探讨干扰素联合宫颈环形电切术治疗宫颈上皮内瘤变的临床疗效.方法选取广东省清远市中医院2009年8月~2011年8月62例宫颈上皮内瘤变的患者,随机分为观察组和对照组,各31例.观察组使用干扰素联合宫颈环形电切术治疗,对照组单纯使用宫颈环形电切术治疗.观察对比两组患者的临床疗效.结果两组患者的手术时间、术中出血量、创面愈合时间对比差异无统计学意义(P>0.05),术后两组患者液基薄层细胞检测检查的异常率相较治疗前均有明显下降,而第2代杂交捕获试验检测人类乳头瘤病毒的阴性率相较治疗前有明显上升(P<0.05).治疗组6、9、12个月的TCT检查异常率明显低于对照组,3、6、9、12个月HC2检测HPV的阴性率明显高于对照组,差异有统计学意义(P<0.05).结论干扰素联合宫颈环形电切术治疗宫颈上皮内瘤变的临床疗效确切.
목적관찰탐토간우소연합궁경배형전절술치료궁경상피내류변적림상료효.방법선취광동성청원시중의원2009년8월~2011년8월62례궁경상피내류변적환자,수궤분위관찰조화대조조,각31례.관찰조사용간우소연합궁경배형전절술치료,대조조단순사용궁경배형전절술치료.관찰대비량조환자적림상료효.결과량조환자적수술시간、술중출혈량、창면유합시간대비차이무통계학의의(P>0.05),술후량조환자액기박층세포검측검사적이상솔상교치료전균유명현하강,이제2대잡교포획시험검측인류유두류병독적음성솔상교치료전유명현상승(P<0.05).치료조6、9、12개월적TCT검사이상솔명현저우대조조,3、6、9、12개월HC2검측HPV적음성솔명현고우대조조,차이유통계학의의(P<0.05).결론간우소연합궁경배형전절술치료궁경상피내류변적림상료효학절.
Objective To observe of interferon combined with cervical loop electrosurgical excision procedure in the treatment of cervical intraepithelial neoplasia clinical efficacy. Methods From August 2011 to August 2009 in our hospital 62 cases of cervical intraepithelial neoplasia patients, divided into 2 groups randomLy, 31 cases in each group. The observation group were treated using interferon in combination with cervical loop electrosurgical excision procedure treatment control group were treated using the treatment of cervical loop electrosurgical excision. Clinical efficacy between two groups of patients were compared. Results Operation time, the amount of bleeding and healing time between two groups had no statistical significance (P<0.05). The abnormal rate of HPV examed by TCT after operation declined sharply when to be compared with before , while the negative rate of HPV detected by HC2 rised obviously then before (P<0.05). The abnormal rate of HPV of observation group was much lower than control group after 6, 9, 12 months, while the negative rate of HPV was much higher than control group after 3, 6, 9, 12 months. Difference between two groups had statistical significance (P<0.05). Conclusion Interferon combined with cervical loop electrosurgical excision procedure has obvious curative effect in the treatment of cervical intraepithelial neoplasia.