当代医学
噹代醫學
당대의학
CHINA CONTEMPORARY MEDICINE
2013年
6期
90-91
,共2页
脑出血%脑含水量%氧自由基%丁苯酞
腦齣血%腦含水量%氧自由基%丁苯酞
뇌출혈%뇌함수량%양자유기%정분태
Cerebral hemorrhage%Brain water content%Oxygen free radical%Butylphthalide
目的研究丁苯酞注射液对大鼠脑出血周围组织含水量及自由基的影响.方法72只SD雄性大鼠随机分为对照组、假手术组、脑出血组、丁苯酞治疗组,每组18只.采用自体血注入法建立大鼠脑出血模型,治疗组应用丁苯酞腹腔注射,一天二次,注射3d.干湿重法测量脑组织含水量.测定脑组织(丙二醛)(MDA)、(超氧化物歧化酶)(SOD)的水平.结果丁苯酞治疗组较脑出血组,血肿周围脑水肿明显减轻(P<0.05),MDA值明显降低(P<0.05),SOD值明显升高(P<0.05).结论丁苯酞注射液能有效清除脑出血后体内产生的大量自由基,减轻脑出血后脑水肿的形成.
目的研究丁苯酞註射液對大鼠腦齣血週圍組織含水量及自由基的影響.方法72隻SD雄性大鼠隨機分為對照組、假手術組、腦齣血組、丁苯酞治療組,每組18隻.採用自體血註入法建立大鼠腦齣血模型,治療組應用丁苯酞腹腔註射,一天二次,註射3d.榦濕重法測量腦組織含水量.測定腦組織(丙二醛)(MDA)、(超氧化物歧化酶)(SOD)的水平.結果丁苯酞治療組較腦齣血組,血腫週圍腦水腫明顯減輕(P<0.05),MDA值明顯降低(P<0.05),SOD值明顯升高(P<0.05).結論丁苯酞註射液能有效清除腦齣血後體內產生的大量自由基,減輕腦齣血後腦水腫的形成.
목적연구정분태주사액대대서뇌출혈주위조직함수량급자유기적영향.방법72지SD웅성대서수궤분위대조조、가수술조、뇌출혈조、정분태치료조,매조18지.채용자체혈주입법건립대서뇌출혈모형,치료조응용정분태복강주사,일천이차,주사3d.간습중법측량뇌조직함수량.측정뇌조직(병이철)(MDA)、(초양화물기화매)(SOD)적수평.결과정분태치료조교뇌출혈조,혈종주위뇌수종명현감경(P<0.05),MDA치명현강저(P<0.05),SOD치명현승고(P<0.05).결론정분태주사액능유효청제뇌출혈후체내산생적대량자유기,감경뇌출혈후뇌수종적형성.
Objective To Study of butylphthalide injection on rat cerebral hemorrhage surrounding tissue water content and the effect of free radicals.Methods SD rats were divided randomly into 4 groups;normal saline group、sham-operated group,ICH group,butylphthalide group. The autologous blood injection method established the rat model of intracerebral hemorrhage,application of the treatment group of butylphthalide intraperitoneal injection, two times a day for three days.the water content of brain was measured by comparion of wet and dry weight in perihematoma, determination of brain MDA, SOD levels. Results In butylphthalide treating group, brain edema around the hematoma alleviated(P<0.05), MDA value decreased significantly(P<0.05), SOD values were significantly elevated(P<0.05)Compared with cerebral hemorrhage group . Conclusion butylphthalide injection can effectively remove a large number of free radicals after intracerebral hemorrhage in vivo produced, reduce the formation of brain edema after intracerebral hemorrhage.
