CAJ | 학술논문

目的探讨小剂量131 I治疗甲状腺功能亢进(甲亢)的临床疗效和副作用的发生情况.方法选择2009年5月~2011年12月经131 I治疗并有复诊记录的甲亢患者124例,根据患者的症状、体征,每3个月口服1次131 I 1.5~2.5 mci并检测甲状腺激素水平,直至甲亢症状、体征好转、甲状腺激素水平正常停药.结果治疗后随访1年以上,124例中,治愈114例,治愈率为91.9%;不同病程、甲状腺肿大程度、突眼的患者之间治愈率差异无统计学意义;14例出现一过性甲状腺功能减低,发生率为11.3%;4例复发,复发率为3.2%;未出现粒细胞减少、甲状腺危象等严重不良反应.结论小剂量131 I治疗甲亢是一种经济、有效、安全、简便的治疗方法.
목적탐토소제량131 I치료갑상선공능항진(갑항)적림상료효화부작용적발생정황.방법선택2009년5월~2011년12월경131 I치료병유복진기록적갑항환자124례,근거환자적증상、체정,매3개월구복1차131 I 1.5~2.5 mci병검측갑상선격소수평,직지갑항증상、체정호전、갑상선격소수평정상정약.결과치료후수방1년이상,124례중,치유114례,치유솔위91.9%;불동병정、갑상선종대정도、돌안적환자지간치유솔차이무통계학의의;14례출현일과성갑상선공능감저,발생솔위11.3%;4례복발,복발솔위3.2%;미출현립세포감소、갑상선위상등엄중불량반응.결론소제량131 I치료갑항시일충경제、유효、안전、간편적치료방법.
Objective To investigate the therapeutic effect and side effect on hyperthyroidism with small dosage 131 I. Methods The dosage of 131 I was from 1.5 mci to 2.5 mci based on the patient’s symptom and signs. Patients took 131 I one time per 3 months until being cured. Results After one year’s follow-up, 114 cases were cured and the cure rate was 91.9%. The incidence rate of hypothyroidism was 11.3%. The recurrence rate was 3.2%. There weren’t any serious adverse reactions. Conclusion The method with small dosage 131 I on hyperthyroidism is economic, effective, safe and simple.