CAJ | 학술논문

目的分析小剂量甲基强的松龙治疗重症手足口病的临床疗效.方法将2008年5月~2009年5月广东佛山市第一人民医院收治的符合重型手足口病的80例患儿随机分成两组.实验组40例,采用利巴韦林、甘露醇、IVIG及甲基强的松龙1~2 mg/(kg?d)治疗;对照组40例,采用利巴韦林、甘露醇、IVIG治疗.比较两组患儿的热退天数、神经系统症状缓解时间及脑脊液改变情况,对小剂量甲基强的松龙的治疗效果进行观察.结果实验组退热时间为(4.8±0.5)d,肢体抖动缓解天数为(8.5±1.5)d;脑脊液恢复正常数率95%;对照组退热时间为(4.9±0.5)d,肢体抖动缓解天数(8.7±1.5)d;脑脊液恢复正常数率92.5%;两组各指标比较差异无统计学意义(P>0.05).结论小剂量甲基强的松龙在治疗手足口病合并脑炎中的效果不明显.
목적분석소제량갑기강적송룡치료중증수족구병적림상료효.방법장2008년5월~2009년5월엄동불산시제일인민의원수치적부합중형수족구병적80례환인수궤분성량조.실험조40례,채용리파위림、감로순、IVIG급갑기강적송룡1~2 mg/(kg?d)치료;대조조40례,채용리파위림、감로순、IVIG치료.비교량조환인적열퇴천수、신경계통증상완해시간급뇌척액개변정황,대소제량갑기강적송룡적치료효과진행관찰.결과실험조퇴열시간위(4.8±0.5)d,지체두동완해천수위(8.5±1.5)d;뇌척액회복정상수솔95%;대조조퇴열시간위(4.9±0.5)d,지체두동완해천수(8.7±1.5)d;뇌척액회복정상수솔92.5%;량조각지표비교차이무통계학의의(P>0.05).결론소제량갑기강적송룡재치료수족구병합병뇌염중적효과불명현.
@@@@Objective Analysis the curative effect of low dose methylprednisolone in the treatment of severe hand-foot-mouth disease. Methods From 2008 to 2009 with severe hand foot and mouth disease in 80 patients were randomly divided into two groups, the experimental group 40 cases with ribavirin, mannitol, IVIG and methylprednisolone in treatment of 1~2 mg/kg?d. The control group of 40 cases with ribavirin, mannitol, IVIG treatment. We compared two groups of patients with fever in days, neurological symptoms remission duration and cerebrospinal fluid to change the situation;To observe the low dose methylprednisolone curative effect. Results The experimental group defervescence time for (4.8±0.5) d, limb shaking remission time (8.5±1.5) d;CSF recovery rate of 95%;the control group (4.9±0.5 fever time) d, limb shaking remission time (8.7 ±1.5) d;CSF recovery rate of 92.5%;each of the two groups index no significant difference (P>0.05). Conclusion A low dose of methylprednisolone in the treatment of hand foot and mouth disease complicated with encephalitis in effect is not obvious.