分子诊断与治疗杂志
分子診斷與治療雜誌
분자진단여치료잡지
JOURNAL OF MOLECULAR DIAGNOSIS AND THERAPY
2013年
1期
1-7
,共7页
肿瘤%MicroRNA(miRNA)%分子诊断%治疗%预测%生物标志物
腫瘤%MicroRNA(miRNA)%分子診斷%治療%預測%生物標誌物
종류%MicroRNA(miRNA)%분자진단%치료%예측%생물표지물
Tumor%MicroRNA(miRNA)%Molecular diagnosis%Therapy%Prediction%Biomarker
MicroRNA(miRNA)在大多真核生物中表达,通过抑制翻译或诱导靶mRNA降解.miRNA是一种新的转录后基因表达调控模式,在复杂疾病形成过程中发挥着重要作用,调节了多种生物学过程,包括生长发育、信号转导、免疫调节、细胞凋亡、增殖及肿瘤发生等.越来越多的证据表明异常表达的miRNA是人类疾病的标志,包括肿瘤.差异表达的miRNA可能作为疾病早期诊断、分子分型及预后判断的指标,同时也可能成为多种肿瘤耐药新的治疗靶标.因此,miRNA在肿瘤中可能作为诊断、预测和治疗的生物标志.
MicroRNA(miRNA)在大多真覈生物中錶達,通過抑製翻譯或誘導靶mRNA降解.miRNA是一種新的轉錄後基因錶達調控模式,在複雜疾病形成過程中髮揮著重要作用,調節瞭多種生物學過程,包括生長髮育、信號轉導、免疫調節、細胞凋亡、增殖及腫瘤髮生等.越來越多的證據錶明異常錶達的miRNA是人類疾病的標誌,包括腫瘤.差異錶達的miRNA可能作為疾病早期診斷、分子分型及預後判斷的指標,同時也可能成為多種腫瘤耐藥新的治療靶標.因此,miRNA在腫瘤中可能作為診斷、預測和治療的生物標誌.
MicroRNA(miRNA)재대다진핵생물중표체,통과억제번역혹유도파mRNA강해.miRNA시일충신적전록후기인표체조공모식,재복잡질병형성과정중발휘착중요작용,조절료다충생물학과정,포괄생장발육、신호전도、면역조절、세포조망、증식급종류발생등.월래월다적증거표명이상표체적miRNA시인류질병적표지,포괄종류.차이표체적miRNA가능작위질병조기진단、분자분형급예후판단적지표,동시야가능성위다충종류내약신적치료파표.인차,miRNA재종류중가능작위진단、예측화치료적생물표지.
MicroRNA (miRNA) is a new mode of post-transcriptional regulation of gene expression. It is expressed in most of the eukaryotes, which can inhibit translation or induce target mRNA degradation. miRNA plays an important role in the formation of complex diseases and regulates a variety of biological processes, including growth and development, signal transduction, immune regulation, apoptosis, proliferation and tumor genesis and so on. More and more evidences show that the abnormal expression of miRNA is a sign of human diseases, including cancer. Differentially expressed miRNA may be used as the indicators of early diagnosis, molecular typing and prognosis. It may also be a variety of tumor-resistant new therapeutic targets. Therefore, miRNA may be used as cancer biomarkers for diagnosis, prediction and treatment.
