CAJ | 학술논문

印第安刺猬蛋白(Ihh)属刺猬蛋白家族成员,参与调节胚胎发育和器官形成. Ihh 通过调控其受体碎片蛋白和平滑蛋白以及下游的锌指转录因子 Gli 等不但维持着颞下颌关节胚胎期的正常发育,而且在脊椎动物或非脊椎动物出生后的下颌髁突和关节盘的生长改建中也起着重要的作用.本文就 Ihh 信号通路、 Ihh 参与软骨内成骨的分子生物学机制、 Ihh 对颞下颌关节生长发育的调控和 Ihh 对颞下颌关节的生物力作用等研究进展作一综述.
인제안자위단백(Ihh)속자위단백가족성원,삼여조절배태발육화기관형성. Ihh 통과조공기수체쇄편단백화평활단백이급하유적자지전록인자 Gli 등불단유지착섭하합관절배태기적정상발육,이차재척추동물혹비척추동물출생후적하합과돌화관절반적생장개건중야기착중요적작용.본문취 Ihh 신호통로、 Ihh 삼여연골내성골적분자생물학궤제、 Ihh 대섭하합관절생장발육적조공화 Ihh 대섭하합관절적생물력작용등연구진전작일종술.
Indian hedgehog(Ihh), one of the members of hedgehog protein family, is essential for embryonic de-velopment and organ formation. The embryonic growth and pathological changes of temporomandibular joint involve complex processes and attract more and more studies. Recent studies have revealed that Ihh not only participates in the embryonic growth of mandibular condyle but also regulates those processes during post-natal life via the cell-surface receptors patched and smoothened and downstream signal of Gli.