CAJ | 학술논문

纳米纤维支架以其良好的生物相容性和生物载体作用,在引导组织再生研究中的应用日益广泛,而将其与基因相结合应用于引导组织再生也成为组织工程研究的重要方向.本文就纳米纤维生物支架的种类和特性及合成,纳米纤维支架与基因结合的意义和方式,基因修饰的电纺纳米纤维膜的合成与结合,基因从纳米纤维支架中的释放,纳米纤维支架的应用和展望等研究进展作一综述.
납미섬유지가이기량호적생물상용성화생물재체작용,재인도조직재생연구중적응용일익엄범,이장기여기인상결합응용우인도조직재생야성위조직공정연구적중요방향.본문취납미섬유생물지가적충류화특성급합성,납미섬유지가여기인결합적의의화방식,기인수식적전방납미섬유막적합성여결합,기인종납미섬유지가중적석방,납미섬유지가적응용화전망등연구진전작일종술.
The tissue engineering scaffolds with nanostructures are now in widespread use in the research of guided tissue regeneration(GTR), because of the good biocompatibility of the scaffolds and their capacity as the vector of bioactive substances. And how to incorporate the gene into the nanofibrous scaffolds is also an important research field in GTR. This paper reviewed the synthesis and characteristics of the nanofibrous scaffolds, the syn-thesis of gene modified electrospun nanofibrous membrane, and the study on the way gene was incorporated into and released from the nanofibrous scaffolds. The importance and manner of incorporating gene into the nanofibrous scaffolds and the application prospect of nanofibrous scaffolds were also outlined.