国际口腔医学杂志
國際口腔醫學雜誌
국제구강의학잡지
JOURNAL OF INTERNATIONAL STOMATOLOGY
2013年
1期
72-75
,共4页
整联蛋白%口腔鳞状细胞癌%侵袭转移%上皮—间质转化%程序性细胞死亡
整聯蛋白%口腔鱗狀細胞癌%侵襲轉移%上皮—間質轉化%程序性細胞死亡
정련단백%구강린상세포암%침습전이%상피—간질전화%정서성세포사망
integrin%oral squamous cell carcinoma%invasion and metastasis%epithelial—mesenchymal trans-formation%programmed cell death
整联蛋白(INT)-αvβ6是一类特殊的 INT-亚型,在上皮源性恶性肿瘤组织和创伤愈合组织中高表达,在健康组织和良性肿瘤组织中不表达. INT-αvβ6通过促进肿瘤细胞的迁移、参与细胞外基质降解、激活转化生长因子-β1和抑制肿瘤程序性细胞死亡等途径促进肿瘤的侵袭和转移.本文就 INT-αvβ6、 INT-αvβ6的信号传导、 INT-αvβ6与口腔鳞状细胞癌和 INT-αvβ6与肿瘤预后等研究进展作一综述.
整聯蛋白(INT)-αvβ6是一類特殊的 INT-亞型,在上皮源性噁性腫瘤組織和創傷愈閤組織中高錶達,在健康組織和良性腫瘤組織中不錶達. INT-αvβ6通過促進腫瘤細胞的遷移、參與細胞外基質降解、激活轉化生長因子-β1和抑製腫瘤程序性細胞死亡等途徑促進腫瘤的侵襲和轉移.本文就 INT-αvβ6、 INT-αvβ6的信號傳導、 INT-αvβ6與口腔鱗狀細胞癌和 INT-αvβ6與腫瘤預後等研究進展作一綜述.
정련단백(INT)-αvβ6시일류특수적 INT-아형,재상피원성악성종류조직화창상유합조직중고표체,재건강조직화량성종류조직중불표체. INT-αvβ6통과촉진종류세포적천이、삼여세포외기질강해、격활전화생장인자-β1화억제종류정서성세포사망등도경촉진종류적침습화전이.본문취 INT-αvβ6、 INT-αvβ6적신호전도、 INT-αvβ6여구강린상세포암화 INT-αvβ6여종류예후등연구진전작일종술.
Integrin-αvβ6 is a special integrin subtype, which highly express in cancer and healing wound, but did not express in normal tissue and benign tumor. By promoting tumor cell migration and extracellular matrix degrada-tion, activating cytokine transforming growth factor-β1 and inhibiting tumor cell programmed cell death lead to tumor invasion and metastasis. Further study of integrin-αvβ6 expression and function in oral cancer will help to understand the molecular mechanisms of invasion and metastasis, provide oral squamous cell carcinoma treatment with new ideas and methods.