CAJ | 학술논문

恶性肿瘤严重危害患者的身心健康,早期发现、早期诊断和早期治疗是提高其疗效的关键.血清作为微创检查的常规样本来源,获得普遍认可.多肽具有结构简单、相对分子质量低于1.0×104、特异性强和易于合成等特点,血清多肽组学作为蛋白组学的重要补充,在临床样本中的多肽检测正引起学术界和医药界的高度重视.本文就多肽组学与蛋白质组学的关系、多肽组学在血清中的应用、血清多肽组学在恶性肿瘤中的应用、血清多肽组学在口腔癌中的应用、血清多肽组学存在的问题等研究进展作一综述.
악성종류엄중위해환자적신심건강,조기발현、조기진단화조기치료시제고기료효적관건.혈청작위미창검사적상규양본래원,획득보편인가.다태구유결구간단、상대분자질량저우1.0×104、특이성강화역우합성등특점,혈청다태조학작위단백조학적중요보충,재림상양본중적다태검측정인기학술계화의약계적고도중시.본문취다태조학여단백질조학적관계、다태조학재혈청중적응용、혈청다태조학재악성종류중적응용、혈청다태조학재구강암중적응용、혈청다태조학존재적문제등연구진전작일종술.
Malignant tumors have been a hazard factor to the mental and physical health of human beings. The key to improve curing effectiveness rely on early detection, early diagnosis and early treatment. It is general-ly recognized to use serum as a common measure to have a minimally invasive examination. Being a comple-mentary method of proteomics, serum peptidomics maintain a character of simple structure, less than 1.0×104 molecular weight, high specialty and easy for synthetize, which arouse the academic and medicine attention in clinical proteomics at present. This article intends to review the research progression of serum peptidomics on biomarkers discovery in malignant tumors.