CAJ | 학술논문

炎症和骨丧失是细菌感染性疾病牙周炎的两大特征.近年来,人们通过对其相关性的研究,诞生了一门新的学科——骨骼免疫学,为更好地研究牙周炎的发病机制提供了一个方向.由炎症引发宿主免疫反应进而导致牙槽骨丧失涉及到很多方面,炎症不仅刺激破骨细胞形成,而且干扰骨形成和骨吸收的偶联过程.炎症的发生部位和持续时间都对骨丧失产生了一定的作用.本文将就牙周炎骨丧失机制的新进展作一综述.
염증화골상실시세균감염성질병아주염적량대특정.근년래,인문통과대기상관성적연구,탄생료일문신적학과——골격면역학,위경호지연구아주염적발병궤제제공료일개방향.유염증인발숙주면역반응진이도치아조골상실섭급도흔다방면,염증불부자격파골세포형성,이차간우골형성화골흡수적우련과정.염증적발생부위화지속시간도대골상실산생료일정적작용.본문장취아주염골상실궤제적신진전작일종술.
Periodontal disease is characterized by both inflammation and bone loss. Advances in research in the in-timate relationship of them have resulted in a new field of science called osteoimmunology and provides a context for better understanding the pathogenesis of periodontitis. There are several aspects of the immuno-inflammatory host re-sponse that ultimately results in loss of alveolar bone. Periodontal inflammation not only stimulates osteoclastogenesis, but also interferes with the uncoupling of bone formation and bone resorption. Furthermore, arguments suggest a criti-cal role of the spatial and temporal aspects of inflammation in the periodontium. This review is about the new progress of bone loss’s mechanism in periodontitis.