CAJ | 학술논문

目的研究病毒性肝炎患者血清腺苷脱氨酶(ADA)水平.方法应用全自动生化分析仪检测各型病毒性肝炎患者血清ADA及各项肝功能指标.结果急性肝炎、慢性肝炎、肝炎后肝硬化、重型肝炎患者血清ADA升高比例分别为55%、43.8%、87.9%及70%,肝炎后肝硬化组显著高于急性肝炎组、慢性肝炎组(P分别为0.008、0.000).肝炎后肝硬化组ADA血清水平亦显著高于急性肝炎组、慢性肝炎组(P均为0.003).病毒性肝炎患者血清ADA与门冬氨酸转氨酶、球蛋白、门静脉宽度、脾脏厚度呈显著正相关(r分别为0.214、0.376、0.424、0.306),与白蛋白、胆碱脂酶呈显著负相关(r分别为-0.405、-0.351).结论在病毒性肝炎患者中,血清ADA升高主要反映肝脏储备合成功能逐渐降低,而不能很好反映肝细胞受损及胆汁淤积.
목적연구병독성간염환자혈청선감탈안매(ADA)수평.방법응용전자동생화분석의검측각형병독성간염환자혈청ADA급각항간공능지표.결과급성간염、만성간염、간염후간경화、중형간염환자혈청ADA승고비례분별위55%、43.8%、87.9%급70%,간염후간경화조현저고우급성간염조、만성간염조(P분별위0.008、0.000).간염후간경화조ADA혈청수평역현저고우급성간염조、만성간염조(P균위0.003).병독성간염환자혈청ADA여문동안산전안매、구단백、문정맥관도、비장후도정현저정상관(r분별위0.214、0.376、0.424、0.306),여백단백、담감지매정현저부상관(r분별위-0.405、-0.351).결론재병독성간염환자중,혈청ADA승고주요반영간장저비합성공능축점강저,이불능흔호반영간세포수손급담즙어적.
Objective To study the level of serum adenosine deaminase in patients viral hepatitis. Methods The adenosine deaminase and liver function indexes of the patients were determined by OLYMPUS AU400. Results The rates of increasing serum adenosine deaminase in acute hepatitis,chronic hepatitis, cirrhosis, hepatitis gravis were 55%, 43.8%, 87.9%and 70%, respectively. It was higher in cirrhosis than acute hepatitis, chronic hepatitis(P=0.008, 0.000, respectively). The level of serum adenosine deaminase in cirrhosis patients was higher than that in acute hepatitis patients, chronic hepatitis patients(P=0.003). The serum adenosine deaminase was correlated positively with serum asparate aminotransferase, globulin, the width of portal vein and the thickness of apleen(r=0.214, 0.376, 0.424, 0.306, respectively), it was correlated negatively with serum albumin and cholinesterase (r=-0.405,-0.351, respectively). Conclusion In patients with viral hepatitis, the higher serum adenosine deaminase expressed the decrease of liver synthesization function, it could not reflect the harm of liver cells and cholestasis perfectly.