医学研究与教育
醫學研究與教育
의학연구여교육
MEDICAL RESEARCH AND EDUCATION
2013年
1期
39-42
,共4页
马红献%史建伟%张利众%刘勤英%李中%闫云
馬紅獻%史建偉%張利衆%劉勤英%李中%閆雲
마홍헌%사건위%장리음%류근영%리중%염운
结直肠肿瘤%细丝蛋白A%微淋巴管密度%免疫组织化学
結直腸腫瘤%細絲蛋白A%微淋巴管密度%免疫組織化學
결직장종류%세사단백A%미림파관밀도%면역조직화학
colorectal neoplasms%filamin A%lymphatic microvessel density%immunohistochemistry
目的探讨结直肠腺癌中细丝蛋白A(FLNa)和微淋巴管密度(LMVD)的临床病理意义及二者之间的关系.方法应用免疫组织化学法检测结直肠腺癌患者癌组织及正常结直肠组织中FLNa的表达水平,用D2-40作为标记计数LMVD,分析与临床病理参数的关系及FLNa与LMVD相关性.结果FLNa在结直肠癌组织的阳性表达率低于正常结直肠组织,结直肠癌组织的LMVD值高于正常结直肠组织;FLNa表达水平和LMVD值与肿瘤的肝转移、淋巴结转移和肠壁浸润深度具有相关性;FLNa表达阳性组的LMVD值低于FLNa表达阴性组.结论FLNa的低表达与肿瘤的微淋巴管生成可能共同参与了结直肠腺癌的发生和发展过程,FLNa的低表达促进了微淋巴管的生成.
目的探討結直腸腺癌中細絲蛋白A(FLNa)和微淋巴管密度(LMVD)的臨床病理意義及二者之間的關繫.方法應用免疫組織化學法檢測結直腸腺癌患者癌組織及正常結直腸組織中FLNa的錶達水平,用D2-40作為標記計數LMVD,分析與臨床病理參數的關繫及FLNa與LMVD相關性.結果FLNa在結直腸癌組織的暘性錶達率低于正常結直腸組織,結直腸癌組織的LMVD值高于正常結直腸組織;FLNa錶達水平和LMVD值與腫瘤的肝轉移、淋巴結轉移和腸壁浸潤深度具有相關性;FLNa錶達暘性組的LMVD值低于FLNa錶達陰性組.結論FLNa的低錶達與腫瘤的微淋巴管生成可能共同參與瞭結直腸腺癌的髮生和髮展過程,FLNa的低錶達促進瞭微淋巴管的生成.
목적탐토결직장선암중세사단백A(FLNa)화미림파관밀도(LMVD)적림상병리의의급이자지간적관계.방법응용면역조직화학법검측결직장선암환자암조직급정상결직장조직중FLNa적표체수평,용D2-40작위표기계수LMVD,분석여림상병리삼수적관계급FLNa여LMVD상관성.결과FLNa재결직장암조직적양성표체솔저우정상결직장조직,결직장암조직적LMVD치고우정상결직장조직;FLNa표체수평화LMVD치여종류적간전이、림파결전이화장벽침윤심도구유상관성;FLNa표체양성조적LMVD치저우FLNa표체음성조.결론FLNa적저표체여종류적미림파관생성가능공동삼여료결직장선암적발생화발전과정,FLNa적저표체촉진료미림파관적생성.
Objective To observe the expression level of filamin A (FLNa) and lymphatic microvessel in human colorectal adenocarcinoma tissues,and analyze their correlation. Methods The expression of FLNa and D2-40 in colorectal adenocarcinoma tissues and colorectal normal tissues was examined by immunohistochemistry. We also investigated the correlation between their expression and the clinicopathologic features. Results The positive expression of FLNa in cancer tissues was lower than that in normal colorectal tissues, while the LMVD values in colorectal cancer tissues was higher than that in normal colorectal tissues. Expression of FLNa and LMVD value was correlated with liver metastasis, lymph node metastasis, and the depth of tumor invasion.The mean LMVD in group with FLNa positive was significantly lower than in that with FLNa negative. Conclusion During the occurrence and development of colorectal adenocarcinoma, there is a close relationship between the expression of FLNa and lymphatic microvessel of tumor.