医学研究与教育
醫學研究與教育
의학연구여교육
MEDICAL RESEARCH AND EDUCATION
2013年
1期
43-47
,共5页
肿瘤标志物%X线计算机体层摄影术%联合检测%肺癌纵隔淋巴结转移
腫瘤標誌物%X線計算機體層攝影術%聯閤檢測%肺癌縱隔淋巴結轉移
종류표지물%X선계산궤체층섭영술%연합검측%폐암종격림파결전이
tumor markers%X-ray computed tomography%combined testing%mediastinum lymph node
目的分析CT扫描、肿瘤标志物检测及两种方法联合应用判断淋巴结转移的检出率及检出的灵敏度和准确率,探讨肿瘤标志物联合CT扫描对肺癌淋巴结转移的诊断价值及临床意义.方法选取2010年9月至2011年8月在保定市第三医院住院的肺癌患者110例,其中男性64例,女性46例;年龄41~71岁.使用西门子螺旋CT机扫描,扫描条件:130 kV,110 mAs.采用C-12型肿瘤诊断用蛋白芯片试剂盒进行肿瘤标志物检测.结果CT对纵隔淋巴结转移诊断正确的有33例,敏感性为67.35%,特异性为70.49%;肿瘤标志物对纵隔淋巴结转移诊断的敏感性77.55%,特异性59.02%;肿瘤标志物联合CT检查对纵隔淋巴结转移诊断的敏感性91.84%,特异性65.57%,准确率为77.27%,与单项检查比较,敏感性明显升高(P<0.01).结论应用多种肿瘤标志物蛋白芯片技术和螺旋CT联合分析,相对于单独应用一种检查技术对于肺癌患者纵隔淋巴结转移检出的敏感性、准确率有所增高,可以提高肺癌及纵隔淋巴结转移的诊断和肺癌TNM分期的准确率.
目的分析CT掃描、腫瘤標誌物檢測及兩種方法聯閤應用判斷淋巴結轉移的檢齣率及檢齣的靈敏度和準確率,探討腫瘤標誌物聯閤CT掃描對肺癌淋巴結轉移的診斷價值及臨床意義.方法選取2010年9月至2011年8月在保定市第三醫院住院的肺癌患者110例,其中男性64例,女性46例;年齡41~71歲.使用西門子螺鏇CT機掃描,掃描條件:130 kV,110 mAs.採用C-12型腫瘤診斷用蛋白芯片試劑盒進行腫瘤標誌物檢測.結果CT對縱隔淋巴結轉移診斷正確的有33例,敏感性為67.35%,特異性為70.49%;腫瘤標誌物對縱隔淋巴結轉移診斷的敏感性77.55%,特異性59.02%;腫瘤標誌物聯閤CT檢查對縱隔淋巴結轉移診斷的敏感性91.84%,特異性65.57%,準確率為77.27%,與單項檢查比較,敏感性明顯升高(P<0.01).結論應用多種腫瘤標誌物蛋白芯片技術和螺鏇CT聯閤分析,相對于單獨應用一種檢查技術對于肺癌患者縱隔淋巴結轉移檢齣的敏感性、準確率有所增高,可以提高肺癌及縱隔淋巴結轉移的診斷和肺癌TNM分期的準確率.
목적분석CT소묘、종류표지물검측급량충방법연합응용판단림파결전이적검출솔급검출적령민도화준학솔,탐토종류표지물연합CT소묘대폐암림파결전이적진단개치급림상의의.방법선취2010년9월지2011년8월재보정시제삼의원주원적폐암환자110례,기중남성64례,녀성46례;년령41~71세.사용서문자라선CT궤소묘,소묘조건:130 kV,110 mAs.채용C-12형종류진단용단백심편시제합진행종류표지물검측.결과CT대종격림파결전이진단정학적유33례,민감성위67.35%,특이성위70.49%;종류표지물대종격림파결전이진단적민감성77.55%,특이성59.02%;종류표지물연합CT검사대종격림파결전이진단적민감성91.84%,특이성65.57%,준학솔위77.27%,여단항검사비교,민감성명현승고(P<0.01).결론응용다충종류표지물단백심편기술화라선CT연합분석,상대우단독응용일충검사기술대우폐암환자종격림파결전이검출적민감성、준학솔유소증고,가이제고폐암급종격림파결전이적진단화폐암TNM분기적준학솔.
Objective To analyze the MLNM detection rate, sensitivity and accuracy with spiral CT scanning, tumor markers and both of them and assess the value of the combination of tumor markers and CT scanning in clinic diagnosis of MLNM in lung cancer. Methods 110 cases (male 64, female 46, aged 41 to 47) hospitalized in Baoding No.3 hospital from September 2010 to August 2011 were selected. Radiations were taken with a Siemens spiral CT machine, under 130 kV, 110 mAs. C-12 protein chip system for multi-tumor marker detection was used. Results Positive diagnosis of MLNM with CT was 33, with sensitivity of 67.35%and specificity of 70.49%. As to tumor markers, the sensitivity was 77.55%and the specificity was 59.02%. When combined, the sensitivity was significantly higher (P<0.01) up to 91.84%, and the specificity was 65.57%, the accuracy was 77.27%. Conclusion The combination of Multi-Tumor Marker Protein Chip technique and spiral CT, comparing with either single technique, can significantly increase the diagnosis sensitivity and accuracy of MLNM, furthermore increase the diagnosis accuracy of TNM stages in lung cancer.
