CAJ | 학술논문

[目的]探讨血清高尔基体糖蛋白73(GP73)在各种恶性肿瘤患者血清中表达水平的差异.[方法]采用酶联免疫吸附试验(ELISA)检测消化系统恶性肿瘤91例、呼吸系统恶性肿瘤78例、生殖系统恶性肿瘤52例、泌尿系统恶性肿瘤10例、乳腺癌21例共252例恶性肿瘤患者及50例健康人血清中 GP73水平.[结果]① GP73在消化系统恶性肿瘤中的表达水平(M =77.3μg/L)显著高于其他各组( P <0.01).其中肝癌组的 GP73水平(M =159.6μg/L )显著高于其他各组( P <0.05).②呼吸系统肿瘤中肺癌组血清GP73水平(M =58.2μg/L)高于其他各组( P <0.05).③肝癌组 GP73水平明显高于肺癌组( P <0.05),其他恶性肿瘤组与正常对照组(M =46.2μg/L )比较血清 GP73浓度差异无统计学意义( P >0.05).[结论]GP73在肝癌患者中的表达水平显著升高,肺癌组中血清 GP73水平虽高于正常对照组,但远低于肝癌患者,血清 GP73有可能成为肝癌较好的血清诊断标志物.
[목적]탐토혈청고이기체당단백73(GP73)재각충악성종류환자혈청중표체수평적차이.[방법]채용매련면역흡부시험(ELISA)검측소화계통악성종류91례、호흡계통악성종류78례、생식계통악성종류52례、비뇨계통악성종류10례、유선암21례공252례악성종류환자급50례건강인혈청중 GP73수평.[결과]① GP73재소화계통악성종류중적표체수평(M =77.3μg/L)현저고우기타각조( P <0.01).기중간암조적 GP73수평(M =159.6μg/L )현저고우기타각조( P <0.05).②호흡계통종류중폐암조혈청GP73수평(M =58.2μg/L)고우기타각조( P <0.05).③간암조 GP73수평명현고우폐암조( P <0.05),기타악성종류조여정상대조조(M =46.2μg/L )비교혈청 GP73농도차이무통계학의의( P >0.05).[결론]GP73재간암환자중적표체수평현저승고,폐암조중혈청 GP73수평수고우정상대조조,단원저우간암환자,혈청 GP73유가능성위간암교호적혈청진단표지물.
Objective]To explore the difference of serum Golgi protein 73(GP73) in patients with various malignant tumors .[Methods] ELISA was used to detect serum GP73 in 252 patients with malignant tumors patients including 91 patients with digestive tract cancer , 78 patients with respiratory system malignant tumors ,52 patients with reproductive system malignant tumors ,10 patients with ? urinary system malignant tumors and 21 breast cancer and 50 healthy people .[Results]The expression level of GP73 in digestive tract cancer was 77 .3 μg/L ,which was significantly higher than that in other groups ( P < 0 .05) .The expression level of GP73 in liver cancer group was 159 .6 μg/L ,which was significant higher than that in other groups ( P< 0 .05) .Serum GP73 in lung cancer was 58 .2 μg/L ,which was higher than that in other groups( P < 0 .05) . The expression level of GP73 in liver cancer group was obviously higher than that in lung cancer group ( P <0 .05) .There was no significant difference in serum GP73 between other malignant tumor groups and healthy control group(46 .2 μg/L)( P > 0 .05) .[Conclusion]The expression level of GP73 in liver cancer increases markedly .Serum GP73 in lung cancer group is higher than that in control group ,but very lower than that in liver cancer patients .Serum GP73 may be used as a better serum marker for live cancer .