CAJ | 학술논문

[目的]探讨高危型人乳头状瘤病毒(HPV )负荷量、年龄与宫颈上皮内瘤变分级的相关性.[方法]选择本院2010年1月至2011年12月因液基薄层细胞检测(TCT )异常和第二代杂交捕获实验(HC ‐Ⅱ)阳性行阴道镜下活检患者1376例,按组织学诊断分为慢性宫颈炎、宫颈上皮内瘤变(CIN)Ⅰ、CIN Ⅱ/Ⅲ三组,高危型 HPV(HR‐HPV)负荷量按大小分成5个等级,分析 HR‐HPV 负荷量、年龄与宫颈上皮内瘤变分级的关系.[结果]1376例患者中组织学诊断为慢性宫颈炎686例,CIN Ⅰ292例,CIN Ⅱ/Ⅲ398例,HR‐HPV 负荷量分级与宫颈病变程度比较差异无统计学意义( P >0.05);30~40岁年龄组宫颈病变发病率最高,显著高于<30年龄组及>40岁年龄组,其差异有统计学意义( P <0.05).[结论]HR‐HPV 负荷量与宫颈病变分级无明显关系;30~40岁是宫颈病变发病的高发年龄.
[목적]탐토고위형인유두상류병독(HPV )부하량、년령여궁경상피내류변분급적상관성.[방법]선택본원2010년1월지2011년12월인액기박층세포검측(TCT )이상화제이대잡교포획실험(HC ‐Ⅱ)양성행음도경하활검환자1376례,안조직학진단분위만성궁경염、궁경상피내류변(CIN)Ⅰ、CIN Ⅱ/Ⅲ삼조,고위형 HPV(HR‐HPV)부하량안대소분성5개등급,분석 HR‐HPV 부하량、년령여궁경상피내류변분급적관계.[결과]1376례환자중조직학진단위만성궁경염686례,CIN Ⅰ292례,CIN Ⅱ/Ⅲ398례,HR‐HPV 부하량분급여궁경병변정도비교차이무통계학의의( P >0.05);30~40세년령조궁경병변발병솔최고,현저고우<30년령조급>40세년령조,기차이유통계학의의( P <0.05).[결론]HR‐HPV 부하량여궁경병변분급무명현관계;30~40세시궁경병변발병적고발년령.
Objective] To explore the correlation of high‐risk(HR) human papillomavirus(HPV) load and age with the grade of cervical intraepithelial neoplasia .[Methods] Totally 1376 patients with abnormal TCT and positive HC‐ Ⅱ by colposcopically directed biopsy in our hospital from Jan .2010 to Dec .2011 were cho‐sen .According to histological diagnosis ,all patients were divided into chronic cervicitis group ,CIN Ⅰ group and CIN Ⅱ /Ⅲ group .HR‐HPV load was divided into 5 grades .The correlation of HR‐HPV load and age with the grade of cervical intraepithelial neoplasia was analyzed .[Results]Among the 1376 patients ,there were 1376 patients with chronic cervicitis ,292 patients with CIN Ⅰ and 398 patients with CIN Ⅱ /Ⅲ diagnosed by histology .There was no significant difference between HR‐HPV load and the degree of cervical lesion ( P >0 .05) .The incidence of cervical disease in the group with the age between 30 and 40 years old was the high‐est ,which was markedly higher than that in the group with the age below 30 years old and the group with the age over 40 years old ,and there was significant difference( P < 0 .05) .[Conclusion]There is no obvious corre‐lation between HR‐HPV load and the grade of cervical lesion .The 30 ~ 40 years old is the age with high inci‐dence of cervical lesion .