CAJ | 학술논문

[目的]评价高频振荡通气( HFOV)治疗新生儿重症胎粪吸入综合征(MAS)的疗效.[方法]对本院2008年9月至2011年6月38例重症 MAS 新生儿予 HFOV 治疗.观察 HFOV 治疗前后肺功能变化及病情转归.[结果]38例中治愈31例(81.6%),放弃治疗7例.治疗1~2 h 后动脉氧分压(PaO2)由 HFOV 治疗前的(62.16±23.03)mmHg 上升为(81.69±23.84)mmHg ;吸氧体积分数(FiO2)由 HFOV 治疗1~2 h 的(0.48 ± 0.14)降低为治疗24 h 后的(0.38 ± 0.13);PaO2/FiO2由(173.59±74.44)增加到(237.02±89.22);动脉二氧化碳分压(PaCO2)由(48.95±12.11)mmHg 下降到(41.89±12.69)mmHg ,上述各指标前后比较其差异均有统计学意义( P < 0.05).[结论]HFOV 用于新生儿重症 MAS 疗效好,能较快改善肺氧合功能,改善预后.
[목적]평개고빈진탕통기( HFOV)치료신생인중증태분흡입종합정(MAS)적료효.[방법]대본원2008년9월지2011년6월38례중증 MAS 신생인여 HFOV 치료.관찰 HFOV 치료전후폐공능변화급병정전귀.[결과]38례중치유31례(81.6%),방기치료7례.치료1~2 h 후동맥양분압(PaO2)유 HFOV 치료전적(62.16±23.03)mmHg 상승위(81.69±23.84)mmHg ;흡양체적분수(FiO2)유 HFOV 치료1~2 h 적(0.48 ± 0.14)강저위치료24 h 후적(0.38 ± 0.13);PaO2/FiO2유(173.59±74.44)증가도(237.02±89.22);동맥이양화탄분압(PaCO2)유(48.95±12.11)mmHg 하강도(41.89±12.69)mmHg ,상술각지표전후비교기차이균유통계학의의( P < 0.05).[결론]HFOV 용우신생인중증 MAS 료효호,능교쾌개선폐양합공능,개선예후.
Objective]To evaluate the efficacy of high‐frequency oscillation ventilation(HFOV) for the treatment of neonates with severe meconium aspiration syndrome (MAS) .[Methods]Thirty‐eight neonates with severe MAS in our hospital from Sept .2008 to June 2011 were given HFOV treatment .The changes of pulmonary function and the prognosis were observed before and after HFOV treatment .[Results]Among 38 patients ,31 patients(81 .6% ) were cured and 7 patients abandoned the therapy .After 1 ~ 2 h of treatment with HFOV ,PaO2 increased from (62 .16 ± 23 .03)mmHg to (81 .69 ± 23 .84)mmHg ,and FiO2 decreased from (0 .48 ± 0 .14) 1 ~ 2h before HFOV to (0 .38 ± 0 .13) 24h after HFOV ,and PaO2 /FiO2 increased from (173 .59 ± 74 .44) to (237 .02 ± 89 .22) ,and PaCO2 de‐creased from (48 .95 ± 12 .11)mmHg to (41 .89 ± 12 .69)mmHg .There were significant differences in above indexes before and after treatment ( P < 0 .05) .[Conclusion]HFOV for the treatment of neonates with severe MAS has good efficacy ,and can improve pulmonary function and prognosis .