CAJ | 학술논문

[目的]探讨慢性阻塞性肺疾病(COPD)患者血清1,25羟‐维生素 D3[l ,25(OH)2 D3]水平与肺功能等指标的关系.[方法]选取年龄、性别、吸烟史及体重指数(BMI)具可比性的稳定期 COPD 患者133例及对照组(健康体检者)61例,测量受试者血清 l ,25(OH)2 D3、血清钙水平及肺功能,比较 COPD 组与对照组,以及不同病情严重程度的 COPD 患者间上述测量指标的差异.[结果]COPD 组血清1,25(OH)2 D3及血清钙值均低于对照组( P <0.01).按病情严重程度分级后,轻度 COPD 患者 l ,25(OH)2 D3水平与对照组无统计学差异( P >0.05),而中度、重度及极重度 COPD 患者 l ,25(OH)2 D3水平均低于对照组( P <0.05),且 COPD患者 l ,25(OH)2 D3水平随病情严重程度分级的增加而降低(各组间 P <0.05).线性相关分析显示,COPD组患者第1秒用力呼气流量(FEV1%)与年龄、BMI 无关( P >0.05),而与 l ,25(OH)2 D3、血清钙水平相关( P <0.01).校正年龄、BMI 、血清钙后,COPD 组患者 FEV1%与 l ,25(OH)2 D3正相关( P <0.01).[结论]COPD 患者血清 l ,25(OH)2 D3水平低于健康对照者,并和病情严重程度相关.
[목적]탐토만성조새성폐질병(COPD)환자혈청1,25간‐유생소 D3[l ,25(OH)2 D3]수평여폐공능등지표적관계.[방법]선취년령、성별、흡연사급체중지수(BMI)구가비성적은정기 COPD 환자133례급대조조(건강체검자)61례,측량수시자혈청 l ,25(OH)2 D3、혈청개수평급폐공능,비교 COPD 조여대조조,이급불동병정엄중정도적 COPD 환자간상술측량지표적차이.[결과]COPD 조혈청1,25(OH)2 D3급혈청개치균저우대조조( P <0.01).안병정엄중정도분급후,경도 COPD 환자 l ,25(OH)2 D3수평여대조조무통계학차이( P >0.05),이중도、중도급겁중도 COPD 환자 l ,25(OH)2 D3수평균저우대조조( P <0.05),차 COPD환자 l ,25(OH)2 D3수평수병정엄중정도분급적증가이강저(각조간 P <0.05).선성상관분석현시,COPD조환자제1초용력호기류량(FEV1%)여년령、BMI 무관( P >0.05),이여 l ,25(OH)2 D3、혈청개수평상관( P <0.01).교정년령、BMI 、혈청개후,COPD 조환자 FEV1%여 l ,25(OH)2 D3정상관( P <0.01).[결론]COPD 환자혈청 l ,25(OH)2 D3수평저우건강대조자,병화병정엄중정도상관.
Objective]To explore the relationship between serum 1 ,25(OH)2 D3 and pulmonary function in patients with chronic obstructive pulmonary disease (COPD) .[Methods]A total of 133 stable stage COPD pa‐tients and 61 healthy subjects whose gender ,age ,smoking history and body mass index (BMI) had compara‐bility were selected .Serum levels of 1 ,25(OH )2 D3 and calcium and pulmonary function were measured .The difference in above indicators between COPD group and control group and among different degrees of disease severity was calculated .[Results] Serum levels of 1 ,25(OH)2 D3 and calcium in COPD group were significant‐ly lower than those in control group( P < 0 .01) .After the classification of the severity ,there was no signifi‐cant difference in serum 1 ,25(OH)2 D3 between mild COPD group and control group ( P > 0 .05) ,but serum 1 ,25(OH)2 D3 in COPD patients decreased with the increasing of severity (P < 0 .05) .Linear correlation analy‐sis showed that FEV1% had no association with age and BMI ( P > 0 .05) ,but was related with serum levels of 1 ,25(OH)2 D3 and calcium( P < 0 .01) .After adjustment of age ,BMI and serum calcium ,FEV1% is posi‐tively correlated with serum 1 ,25(OH)2 D3 ( P < 0 .01) .[Conclusion] Serum 1 ,25(OH)2 D3 in COPD patients is lower than that in healthy controls ,and correlated with the severity of the disease .