CAJ | 학술논문

[目的]探讨2型糖尿病(T2DM )合并冠心病(CHD)与炎性因子的相关性.[方法]按是否合并CHD ,将2009年1月至2012年6月怀化市第二人民医院收治的176例 T2DM 患者分为观察组( n =75)与对照组( n =101),观察组患者为合并 CHD 患者,对照组患者为未合并 CHD 患者.检测两组患者的 C 反应蛋白(CRP)、白介素‐6(IL‐6)、肿瘤坏死因子‐α(TNF‐α)水平,并采用 Pearson 法分析观察组患者上述炎性因子的相关性.[结果]①观察组外周血 CRP 、IL‐6、TNF‐α水平均显著高于对照组( P <0.05).②观察组患者外周血 CRP 与 IL‐6呈正相关( P <0.05),IL‐6与 TNF‐α呈正相关( P <0.05),TNF‐α与 CRP 呈正相关( P <0.05).[结论]T2DM 合并 CHD 患者外周血存在高水平的 CRP 、IL‐6、TNF‐α,且上述3种炎性因子之间呈显著的正相关.
[목적]탐토2형당뇨병(T2DM )합병관심병(CHD)여염성인자적상관성.[방법]안시부합병CHD ,장2009년1월지2012년6월부화시제이인민의원수치적176례 T2DM 환자분위관찰조( n =75)여대조조( n =101),관찰조환자위합병 CHD 환자,대조조환자위미합병 CHD 환자.검측량조환자적 C 반응단백(CRP)、백개소‐6(IL‐6)、종류배사인자‐α(TNF‐α)수평,병채용 Pearson 법분석관찰조환자상술염성인자적상관성.[결과]①관찰조외주혈 CRP 、IL‐6、TNF‐α수평균현저고우대조조( P <0.05).②관찰조환자외주혈 CRP 여 IL‐6정정상관( P <0.05),IL‐6여 TNF‐α정정상관( P <0.05),TNF‐α여 CRP 정정상관( P <0.05).[결론]T2DM 합병 CHD 환자외주혈존재고수평적 CRP 、IL‐6、TNF‐α,차상술3충염성인자지간정현저적정상관.
Objective]To explore the correlation between type 2 diabetes mellitus(T2DM ) with coronary heart disease(CHD) and inflammatory factors .[Methods] According to with or without CHD ,176 T2DM pa‐tients admitted into Second People's Hospital of Huaihua City from Jan .2009 to June 2012 were divided into observation group( n = 75) and control group ( n = 101) .The observation group was T2DM patients with CHD ,while the control group was T2DM patients without CHD .The differences of C‐reactive protein(CRP) , interleukin‐6(IL‐6) and tumor necrosis factor‐alpha (TNF‐α) in peripheral blood between observation group and control group were analyzed by U test .The correlations among these before‐mentioned inflammatory fac‐tors in observation group were analyzed by Pearson methods .[Results] CRP ,IL‐6 and TNF‐α in peripheral blood of observation group were significantly higher than those in control group ( P < 0 .05) .In observation group ,CRP in peripheral blood was positively correlated with IL‐6( P < 0 .05) ,and IL‐6 was positively corre‐lated with TNF‐α( P < 0 .05) ,and TNF‐α was positively correlated with CRP ( P < 0 .05) .[Conclusion] The levels of CRP ,IL‐6 and TNF‐α in peripheral blood of T2DM patients with CHD are high .There are positive correlations among above three inflammatory factors .