中医药导报
中醫藥導報
중의약도보
GUIDING JOURNAL OF TCM
2013年
2期
88-89
,共2页
屈波%蔡光先%董晓斐%刘柏炎%刘红萍
屈波%蔡光先%董曉斐%劉柏炎%劉紅萍
굴파%채광선%동효비%류백염%류홍평
护心康%动脉粥样硬化%兔%TLR4mRNA%丹参%瓜蒌
護心康%動脈粥樣硬化%兔%TLR4mRNA%丹參%瓜蔞
호심강%동맥죽양경화%토%TLR4mRNA%단삼%과루
Huxinkang%Atherosclerosis%Rabbit%TLR4mRNA%Salvia%Trichosanthes
目的:研究护心康对兔动脉粥样硬化防治的作用机制.方法:采用高脂喂饲复制兔动脉粥样硬化模型,将护心康分为低、中、高3个不同剂量组进行干预治疗,原位杂交法检测动脉管壁TLR4mRNA的变化.结果:护心康中、高剂量均有较好的降低兔动脉管壁TLR4mRNA的作用,高剂量作用优于低剂量,差异有统计学意义(P<0.05).结论:护心康具有降低动脉管壁TLR4mRNA的功效.
目的:研究護心康對兔動脈粥樣硬化防治的作用機製.方法:採用高脂餵飼複製兔動脈粥樣硬化模型,將護心康分為低、中、高3箇不同劑量組進行榦預治療,原位雜交法檢測動脈管壁TLR4mRNA的變化.結果:護心康中、高劑量均有較好的降低兔動脈管壁TLR4mRNA的作用,高劑量作用優于低劑量,差異有統計學意義(P<0.05).結論:護心康具有降低動脈管壁TLR4mRNA的功效.
목적:연구호심강대토동맥죽양경화방치적작용궤제.방법:채용고지위사복제토동맥죽양경화모형,장호심강분위저、중、고3개불동제량조진행간예치료,원위잡교법검측동맥관벽TLR4mRNA적변화.결과:호심강중、고제량균유교호적강저토동맥관벽TLR4mRNA적작용,고제량작용우우저제량,차이유통계학의의(P<0.05).결론:호심강구유강저동맥관벽TLR4mRNA적공효.
Objective: To explore the mechanism of Huxinkang on atherosclerosis rabbit . Methods:Atherosclerosis rabbits were induced by high lipid diet. The rabbits were divided into Huxinkang low, middle and high dose groups. The samples of aorta were taken for TLR4mRNA in the AS plaque. Results: The expression of TLR4mRNA in AS plaque were all increased obviously in the Huxinkang low, middle and high dose groups. The high dose group is better than low dose group (P<0.05) . Conclusion: Huxinkang can decrease TLR4mRNA in plaque.
