CAJ | 학술논문

目的:观察咳喘宁对哮喘豚鼠Eotaxin的调节作用.方法:将40只豚鼠随机分为:正常对照组,不做任何处理;模型组,用卵清蛋白诱喘;咳喘宁治疗组,使用卵清蛋白诱发哮喘后,用咳喘宁治疗;地塞米松组,使用卵清蛋白诱发哮喘后用地塞米松治疗.采用酶联免疫双抗体夹心(ELISA)法检测各组血中和肺泡灌洗液中Eotaxin的水平.结果:与模型组比较,咳喘宁组血和肺泡灌洗液中的Eotaxin水平明显降低,差异有统计学意义(P<0.05),其作用与地塞米松比较,差异无统计学意义(P﹥0.05).结论:咳喘宁防治哮喘的作用机制与降低Eotaxin水平有关.
목적:관찰해천저대효천돈서Eotaxin적조절작용.방법:장40지돈서수궤분위:정상대조조,불주임하처리;모형조,용란청단백유천;해천저치료조,사용란청단백유발효천후,용해천저치료;지새미송조,사용란청단백유발효천후용지새미송치료.채용매련면역쌍항체협심(ELISA)법검측각조혈중화폐포관세액중Eotaxin적수평.결과:여모형조비교,해천저조혈화폐포관세액중적Eotaxin수평명현강저,차이유통계학의의(P<0.05),기작용여지새미송비교,차이무통계학의의(P﹥0.05).결론:해천저방치효천적작용궤제여강저Eotaxin수평유관.
Objective: To observe the effect of Kechuanning on adjusting Eotaxin in asthma Guinea pigs. Methods: Forty Guinea pigs were randomized into the control group (CG),model group(MG), Kechuanning pretreated group (KPG) and dexam-ethasone pretreated group (DPG).The animals in MG、KPG and DPG were given egg albumin to establish the model of asthma. The animals in KPG were treated with Kechuanning; and the animals in DPG were treated with dexamethasone. The counts of total Eotaxin in serum and in bronchoa1veolar lavage(BALF) were measured according to ELISA.Results: Compared with MG, the contents of Eotaxin in serum and BALF were marked decreased in the guinea pigs of KPG(P<0.05), and there was no significant difference between KPG and DPG(P>0.05).Conclusion: The mechanism of preventing and curing asthma of Kechuan-ning was related with decreasing the lever of Eotaxin.