CAJ | 학술논문

研究富金花茯散茶对氧嗪酸钾致高尿酸血症小鼠的尿酸代谢与相关酶活性的影响.将60只雄性KM种小鼠随机分为空白组、模型组、阳性药组(别嘌呤醇)、茯茶低剂量组(125 mg/kg)、茯茶中剂量组(250 mg/kg)、茯茶高剂量组(500 mg/kg).连续灌胃7 d后腹腔注射氧嗪酸钾(300 mg/kg)造模,空白组注射等量蒸馏水.采样后测定小鼠血尿酸(UA)、肝脏黄嘌呤氧化酶(XOD)、腺苷脱氨酶(ADA)活性.造模后,茯茶高剂量组血尿酸浓度较对照组降低35.2%(P<0.05),肝脏XOD及ADA活性抑制率显著,XOD活性降低38%(P<0.05), ADA活性降低53.8%(P<0.05).富金花茯散茶对氧嗪酸钾导致的高尿酸血症有明显的改善作用,其作用机制与其抑制肝脏XOD、ADA活性有关.
연구부금화복산다대양진산갑치고뇨산혈증소서적뇨산대사여상관매활성적영향.장60지웅성KM충소서수궤분위공백조、모형조、양성약조(별표령순)、복다저제량조(125 mg/kg)、복다중제량조(250 mg/kg)、복다고제량조(500 mg/kg).련속관위7 d후복강주사양진산갑(300 mg/kg)조모,공백조주사등량증류수.채양후측정소서혈뇨산(UA)、간장황표령양화매(XOD)、선감탈안매(ADA)활성.조모후,복다고제량조혈뇨산농도교대조조강저35.2%(P<0.05),간장XOD급ADA활성억제솔현저,XOD활성강저38%(P<0.05), ADA활성강저53.8%(P<0.05).부금화복산다대양진산갑도치적고뇨산혈증유명현적개선작용,기작용궤제여기억제간장XOD、ADA활성유관.
It is to study the effect of “Fu Jinhua”Fuzhuan brick tea on the level of uric acid in hyperuricemia mice and to investigate the mechanism initally. Methods: sixty KM mice were divided into normal group,model group, positive drug group(Allopurinol),Fuzhuan low group(125 mg/kg),Fuzhuan middle group(250 mg/kg), Fuzhuan high group(500 mg/kg).Ig 7 days after intarperitoneal injection the potassium oxonate(300 mg/kg)for model,control group were with distilled water. Determination of serum uric acid (UA), liver xanthine oxidase (XOD), adenosine deaminase (ADA) activity. Results: After modeling,the Fuzhuan high group decreased serum uric acid level by 35.2%(P<0.05)respectively. Hepatic XOD and ADA activities were reduced significantly by Fuzhuan treatment. Dietary Fuzhuan treatment reduced XOD activity by 38%(P<0.05),and reduced ADA activity by 53.8%(P<0.05). Conclusions: Fuzhuan brick tea possesses a potent anti-hyperuricemic effect on potassium oxonate induced hyperuricemia,and the mechanism is relevant in decreasing the activity of liver XOD and ADA.