CAJ | 학술논문

介绍了含有烯二炔骨架结构的天然产物及其类似物研究工作新进展.该类化合物是目前所知的抗癌抗菌功效最强的化合物之一,其独特的结构,在成环过程中产生的双自由基裂解DNA的作用机理,以及新颖的合成方法是目前化学和生物学研究的热点课题.
개소료함유희이결골가결구적천연산물급기유사물연구공작신진전.해류화합물시목전소지적항암항균공효최강적화합물지일,기독특적결구,재성배과정중산생적쌍자유기렬해DNA적작용궤리,이급신영적합성방법시목전화학화생물학연구적열점과제.
The recent discovery of several potent antitumor antibiotics containing enediynes or analogues and models of enediyne has pushed the exploration of enediynes to the forefront of chemical and biological research. Not only their unique structural features, But the most fascinating aspect is their unprecedented mechanism of the cleavage DNA that originates from the chemical reactivity of the enediyne moiety. Novel and more efficient approaches to the enediyne functionality were also discussed.