CAJ | 학술논문

合成了三-(4-甲基苯甲酸)纤维素酯(MCTB)手性固定相,用反相高效液相色谱法在该手性固定相上对布洛芬酯的对映体进行分离.实验结果表明,在三-(4-甲基苯甲酸)纤维素酯手性固定相上,以V(甲醇)/V(水)=85/15为流动相能较好地分离布洛芬甲酯、乙酯、丙酯对映体,其分离因子为1.17、1.29和1.27;同时还发现在三-(4-甲基苯甲酸)纤维素酯手性固定相上布洛芬酯的酯基团的大小对其对映体的分离有明显的影响,其中以乙酯最佳.
합성료삼-(4-갑기분갑산)섬유소지(MCTB)수성고정상,용반상고효액상색보법재해수성고정상상대포락분지적대영체진행분리.실험결과표명,재삼-(4-갑기분갑산)섬유소지수성고정상상,이V(갑순)/V(수)=85/15위류동상능교호지분리포락분갑지、을지、병지대영체,기분리인자위1.17、1.29화1.27;동시환발현재삼-(4-갑기분갑산)섬유소지수성고정상상포락분지적지기단적대소대기대영체적분리유명현적영향,기중이을지최가.
Tri-(4-methylbenzoate) cellulose chiral stationary phase (MCTB) was prepared. Separation of enantiomers of ibuprofen esters had been investigated by reversed-phase high-performance liquid chromatography on the chiral stationary phase. The experimental results showed that the separation of enantiomers of the methyl, ethyl and n-propyl esters of ibuprofen could be achieved on the tri-(4-methylbenzoate) cellulose chiral stationary phase (MCTB) using methanol and water (V(methanol)/V(water)=85/15,) as mobile phase. Their separation factors were 1.17, 1.29, 1.27, respectively. At the same time, It was found that the size of the ester group obviously affected the separation efficiency of their enantiomers on the MCTB chiral stationary phase. The separation of the ethyl ester was most satisfactory.