化学通报（网络版）
化學通報（網絡版）
화학통보（망락판）
Chemistry Online
2006年
1期
1-6
,共6页
胡代娣%周荫庄*%屠淑洁
鬍代娣%週蔭莊*%屠淑潔
호대제%주음장*%도숙길
锌化合物%拟胰岛素活性%配位模式%构效关系
鋅化閤物%擬胰島素活性%配位模式%構效關繫
자화합물%의이도소활성%배위모식%구효관계
Zinc complexes%Insulinomimetic activity%Coordination mode%Structure-activity relationship
锌化合物具有拟胰岛素活性.鉴于锌化合物的生物兼容性好、价态稳定及体内、外作用明显等特点,故有望研制出高效低毒的用于治疗糖尿病候选药物.目前该领域新化合物的合成、结构表征及构效关系的研究甚为活跃,对多种不同配位模式锌配合物相关性质的研究已取得可喜成果.本文介绍了近年来该领域的研究进展.
鋅化閤物具有擬胰島素活性.鑒于鋅化閤物的生物兼容性好、價態穩定及體內、外作用明顯等特點,故有望研製齣高效低毒的用于治療糖尿病候選藥物.目前該領域新化閤物的閤成、結構錶徵及構效關繫的研究甚為活躍,對多種不同配位模式鋅配閤物相關性質的研究已取得可喜成果.本文介紹瞭近年來該領域的研究進展.
자화합물구유의이도소활성.감우자화합물적생물겸용성호、개태은정급체내、외작용명현등특점,고유망연제출고효저독적용우치료당뇨병후선약물.목전해영역신화합물적합성、결구표정급구효관계적연구심위활약,대다충불동배위모식자배합물상관성질적연구이취득가희성과.본문개소료근년래해영역적연구진전.
Zinc compounds have insulinomimetic activity. Zinc compounds has been proposed as candidates for treating of diabetes mellitus, because it has been found to have relatively high insulin-mimetic properties and it is thought to be less toxic than other metal elements. The design and application of the synthesis of the zinc complexes have received considerable attention during the last decade. The research progress on the studies of its biological activities and structure-activity relationship in this field have been introduced in this paper.
