化学通报（网络版）
化學通報（網絡版）
화학통보（망락판）
Chemistry Online
2007年
1期
1-5
,共5页
王陆瑶%胡文祥%杨秉勤%史真*
王陸瑤%鬍文祥%楊秉勤%史真*
왕륙요%호문상%양병근%사진*
2-取代苯并咪唑衍生物库%微波辐射%平行合成
2-取代苯併咪唑衍生物庫%微波輻射%平行閤成
2-취대분병미서연생물고%미파복사%평행합성
2-Substituted benzimidazole library%Microwave%Parallel synthesis
以邻苯二胺及相应羧酸为原料,于多聚磷酸存在下,由微波辐射平行合成了一个小型2-取代苯并咪唑衍生物库,反应时间由常规加热的几小时到几天缩短为20min,且产率较高.经元素分析和1H NMR确证了产物结构.
以鄰苯二胺及相應羧痠為原料,于多聚燐痠存在下,由微波輻射平行閤成瞭一箇小型2-取代苯併咪唑衍生物庫,反應時間由常規加熱的幾小時到幾天縮短為20min,且產率較高.經元素分析和1H NMR確證瞭產物結構.
이린분이알급상응최산위원료,우다취린산존재하,유미파복사평행합성료일개소형2-취대분병미서연생물고,반응시간유상규가열적궤소시도궤천축단위20min,차산솔교고.경원소분석화1H NMR학증료산물결구.
A minilibrary of 18 kinds of 2-substituted benzimidazole derivatives was synthesized by the reaction of o-phenylenediamine with the corresponding acid in the presence of PPA under microwave irradiation. The compounds were obtained in good yields and the reaction time was shortened to 20min. The compounds were characterized by elemental analysis and 1H NMR.
