CAJ | 학술논문

地特胰岛素是一种新型的基础胰岛素类似物,其入血后可形成独特的双六聚体-白蛋白复合物,发挥长效降糖作用.地特胰岛素疗效可靠,并具有低血糖发生率低、个体内变异性小、体重增加少等临床特点,而体重增加少更是其独特的优势.多项临床研究表明,“基础+口服药”治疗(BOT)方案中每天1次使用地特胰岛素能够达到有效控制血糖的目标.采用303算法或者医生指导调节胰岛素用量可获得同样的效果.
지특이도소시일충신형적기출이도소유사물,기입혈후가형성독특적쌍륙취체-백단백복합물,발휘장효강당작용.지특이도소료효가고,병구유저혈당발생솔저、개체내변이성소、체중증가소등림상특점,이체중증가소경시기독특적우세.다항림상연구표명,“기출+구복약”치료(BOT)방안중매천1차사용지특이도소능구체도유효공제혈당적목표.채용303산법혹자의생지도조절이도소용량가획득동양적효과.
Insulin detemir is a new basal insulin analogue, which could form the dual hexamer-albumin complex in the blood to have a prolonged hypoglycemic effect. Its clinical efficacy is quite satisfactory, with low incidence of hypoglycemia, low within-subject variability in blood glucose concentration, less weight gain and other clinical features, and less weight gain is the unique advantage. A number of trials have shown that BOT (“basal+oral”therapy) with once-daily detemir achieved effective control of blood glucose. To adjust the dose of insulin, there is no significant difference between 303 algorithm and doctor’s guidance.