CAJ | 학술논문

血脂异常是动脉粥样硬化性心脑血管疾病的重要危险因素.他汀类药物通过降低低密度脂蛋白胆固醇水平,使心血管事件明显减少.但是即使采用大剂量的他汀类药物仍难以达到指南要求的血脂水平标准,因此针对合并糖尿病、代谢综合征等心血管高危人群,他汀类药物联合贝特类、烟酸类、胆固醇吸收抑制药等药物成为临床上的重要选择.
혈지이상시동맥죽양경화성심뇌혈관질병적중요위험인소.타정류약물통과강저저밀도지단백담고순수평,사심혈관사건명현감소.단시즉사채용대제량적타정류약물잉난이체도지남요구적혈지수평표준,인차침대합병당뇨병、대사종합정등심혈관고위인군,타정류약물연합패특류、연산류、담고순흡수억제약등약물성위림상상적중요선택.
Dyslipidemia is an important risk factor for atherosclerotic cardio-cerebro-vascular diseases. Clinical studies have shown that statins could signifi cantly reduced cardiovascular events by reducing the level of low density lipoprotein cholesterol. However, it is difficult to achieve standard serum lipid levels recommended by guideline even with high doses of statins. For high-risk groups with diabetes or metabolic syndrome, the combination of statins and fibrates, niacin, cholesterol absorption inhibitors would be a preferable alternative in clinical.