CAJ | 학술논문

目的:探讨EphA2和E-cad在NSCLC(non-small cell lung cancer,非小细胞肺癌)中的表达情况及与临床病理特征的关系,并研究EphA2过表达与E-cad表达的相关性,探讨EphA2过表达可能的机制,筛选出能反映肿瘤预后的相关指标.方法:运用免疫组织化学Envision法检测62例NSCLC中EphA2和E-cad的表达情况.结果:1.EphA2在62例NSCLC的阳性表达率为50%(31/62),EphA2的阳性表达率与有淋巴结转移、临床分期晚、5a生存率有关(P<0.05),而与患者吸烟与否、肿瘤的组织学类型和分化程度无关(P>0.05). EphA2阴性组的生存时间长于阳性组,有统计学意义(P<0.01).2.E-cad在62例NSCLC的异常表达率为53.2%,E-cad的异常表达率与有淋巴结转移、临床分期晚和5a生存率有关(P<0.01).与患者吸烟与否、肿瘤的组织学类型和分化程度无关(P>0.05),E-cad正常表达组的生存时间长于异常表达组,有统计学意义(P<0.01).3.EphA2与E-cad的表达呈负相关性(P<0.01).结论:在NSCLC中EphA2的过表达及E-cad的低表达与肿瘤的淋巴结转移、临床分期及术后生存时间有关,因此可作为判断NSCLC预后的指标.
목적:탐토EphA2화E-cad재NSCLC(non-small cell lung cancer,비소세포폐암)중적표체정황급여림상병리특정적관계,병연구EphA2과표체여E-cad표체적상관성,탐토EphA2과표체가능적궤제,사선출능반영종류예후적상관지표.방법:운용면역조직화학Envision법검측62례NSCLC중EphA2화E-cad적표체정황.결과:1.EphA2재62례NSCLC적양성표체솔위50%(31/62),EphA2적양성표체솔여유림파결전이、림상분기만、5a생존솔유관(P<0.05),이여환자흡연여부、종류적조직학류형화분화정도무관(P>0.05). EphA2음성조적생존시간장우양성조,유통계학의의(P<0.01).2.E-cad재62례NSCLC적이상표체솔위53.2%,E-cad적이상표체솔여유림파결전이、림상분기만화5a생존솔유관(P<0.01).여환자흡연여부、종류적조직학류형화분화정도무관(P>0.05),E-cad정상표체조적생존시간장우이상표체조,유통계학의의(P<0.01).3.EphA2여E-cad적표체정부상관성(P<0.01).결론:재NSCLC중EphA2적과표체급E-cad적저표체여종류적림파결전이、림상분기급술후생존시간유관,인차가작위판단NSCLC예후적지표.
Objective:To investigate the expression level of EphA 2 and E-cad in non-small cell lung cancer (NSCLC) and their relationship with the clinicopathological features .To study the correlation among the expression of EphA 2 and E-cad.To screen the possible index to predict the prognosis of NSCLC patients .Methods:To investigate the expression level of EphA 2 and E-cad in 62 ca-ses of NSCLC by Envision immunohistochemical method .Results:1.Overexpression of EphA2 in 62 NSCLC specimens was 50%.E-phA2 levels did not appear to relate to smoke , histological type or differentiation , but did relate to lymph node metastasis , clinical stage (P<0.01) and 5 year survival rate(P<0.05).There was longer survival time in EphA2 negative cases than in positive cases (P<0. 01).2.Abnormal expression rate of E -cad in 62 NSCLC specimens was 53.2%.The abnormal expression rate of E -cad did not ap-pear to relate to smoke, histological type or differentiation, but did relate to lymph node metastasis , clinical stage and 5 year survival rate(P<0.01).There was longer survival time in E -cad normal expression cases than in abnormal expression cases and their differ -ence was significant(P<0.01) 3.Expression of EphA2 correlate to E-cad abnormal expression(P<0.01).Conclusion:The overex-pression of EphA2 and low expression of E -cad are observed in NSCLC, which might be related to lymph node metastasis、clinical stage and survival time.Hence they might Be contribute to prognostic judgment .