CAJ | 학술논문

以对溴苯酚为原料,引进醋酸保护基,经四步反应合成一种新型取代苯乙炔单体(3,5-二(羟甲基)-4-羟基-1-(三甲基硅乙炔基)苯),最后经核磁氢谱表征确定了各步产物化学结构.提供一种简便有效的合成方法,其原料易得、反应条件温和、后处理方便、产率高.
이대추분분위원료,인진작산보호기,경사보반응합성일충신형취대분을결단체(3,5-이(간갑기)-4-간기-1-(삼갑기규을결기)분),최후경핵자경보표정학정료각보산물화학결구.제공일충간편유효적합성방법,기원료역득、반응조건온화、후처리방편、산솔고.
A new substituted phenylacetylene(3, 5-bis(hydroxymethyl)-4-hydroxyl-1- (trimethylsilylacetylenyl)-benzene) was synthesized by four-step reactions and by using bromophenol as raw materials. And in the synthetic route acetic acid was introduced as protection group. The chemical structures of the each step products were characterized by the NMR spectra. We provided a simple and effective synthetic methods with the easily available raw materials, mild reaction conditions, convenient post-processing, and high yield.