中国伤残医学
中國傷殘醫學
중국상잔의학
CHINESE JOURNAL OF TRAUMA AND DISABILITY MEDICINE
2013年
2期
32-34
,共3页
非典型抗精神病药%精神分裂症%泌乳素
非典型抗精神病藥%精神分裂癥%泌乳素
비전형항정신병약%정신분렬증%비유소
Atypical antipsychotics%Schizophrenia%Prolactin
目的:调查分析6种非典型抗精神病药对男性精神分裂症患者泌乳素水平的影响.方法:将360例精神分裂症患者按照服药情况平均分为6组,于基线时治疗4、8周末测定血清泌乳素水平(PRL).结果:基线时各组间泌乳素水平比较无统计学差异(P>0.05),8周末时与治疗前相比利培酮泌乳素水平增加最为明显(P<0.01),氯氮平、奥氮平、喹硫平泌乳素水平显著增加(P<0.05),阿立哌唑、齐拉西酮泌乳素水平基本没有改变(P>0.05).结论:利培酮对泌乳素水平升高最为明显,阿立哌唑、齐拉西酮对泌乳素水平基本没有影响.
目的:調查分析6種非典型抗精神病藥對男性精神分裂癥患者泌乳素水平的影響.方法:將360例精神分裂癥患者按照服藥情況平均分為6組,于基線時治療4、8週末測定血清泌乳素水平(PRL).結果:基線時各組間泌乳素水平比較無統計學差異(P>0.05),8週末時與治療前相比利培酮泌乳素水平增加最為明顯(P<0.01),氯氮平、奧氮平、喹硫平泌乳素水平顯著增加(P<0.05),阿立哌唑、齊拉西酮泌乳素水平基本沒有改變(P>0.05).結論:利培酮對泌乳素水平升高最為明顯,阿立哌唑、齊拉西酮對泌乳素水平基本沒有影響.
목적:조사분석6충비전형항정신병약대남성정신분렬증환자비유소수평적영향.방법:장360례정신분렬증환자안조복약정황평균분위6조,우기선시치료4、8주말측정혈청비유소수평(PRL).결과:기선시각조간비유소수평비교무통계학차이(P>0.05),8주말시여치료전상비리배동비유소수평증가최위명현(P<0.01),록담평、오담평、규류평비유소수평현저증가(P<0.05),아립고서、제랍서동비유소수평기본몰유개변(P>0.05).결론:리배동대비유소수평승고최위명현,아립고서、제랍서동대비유소수평기본몰유영향.
Objective:To investigate the impact of the six kinds of atypical antipsychotics on prolactin levels in male schizophrenics. Methods: 360 patients with schizophrenia were medication compliance were divided into six groups at baseline and treatment of 4,8 weekend serum prolactin level (PRL). Results:Baseline prolactin levels among the groups showed no significant difference (P> 0.05), the weekend of August before treatment Bili Pei ketone prolactin levels increased most significantly (P <0.01), clozapine, olanzapine The level of quetiapine prolactin levels increased significantly (P <0.05), aripiprazole, ziprasidone basic prolactin levels did not change (P> 0.05). Conclusions:Effects of risperidone on prolactin levels were the most obvious, Aripiprazole, ziprasidone on prolactin level did not affect the basic.
