上海医药
上海醫藥
상해의약
SHANGHAI MEDICAL & PHARMACEUTICAL JOURNAL
2013年
1期
43-48
,共6页
孙占莉*%肖旭华**%袁博
孫佔莉*%肖旭華**%袁博
손점리*%초욱화**%원박
Pim-1 激酶%抗肿瘤 Pim-1 激酶小分子抑制剂
Pim-1 激酶%抗腫瘤 Pim-1 激酶小分子抑製劑
Pim-1 격매%항종류 Pim-1 격매소분자억제제
Pim-1 kinase%antitumor%small-molecular inhibitors of Pim-1 kinase
Pim-1激酶在调控细胞凋亡、分化、增殖以及肿瘤形成等方面发挥非常重要的作用,在白血病、淋巴瘤以及前列腺癌的形成过程中均可发现 Pim-1过度表达.本文通过介绍 Pim-1激酶的特点,综述近几年研发的其小分子抑制剂,为开发新的选择性高效 Pim-1激酶抑制剂提供参考.
Pim-1激酶在調控細胞凋亡、分化、增殖以及腫瘤形成等方麵髮揮非常重要的作用,在白血病、淋巴瘤以及前列腺癌的形成過程中均可髮現 Pim-1過度錶達.本文通過介紹 Pim-1激酶的特點,綜述近幾年研髮的其小分子抑製劑,為開髮新的選擇性高效 Pim-1激酶抑製劑提供參攷.
Pim-1격매재조공세포조망、분화、증식이급종류형성등방면발휘비상중요적작용,재백혈병、림파류이급전렬선암적형성과정중균가발현 Pim-1과도표체.본문통과개소 Pim-1격매적특점,종술근궤년연발적기소분자억제제,위개발신적선택성고효 Pim-1격매억제제제공삼고.
ABSTRACT The Pim-1 kinase plays a pivotal role in the proliferation, survival and malignant transformation of cells, and in particularly, it is frequently overexpressed in prostate cancer, leukemia and lymphoma. This review describes the characteristics of Pim-1 kinase and summarizes recent advances in the small-molecule inhibitors of Pim-1 kinase, which will provide some references for the development of new selective and efficient Pim-1 kinase inhibitors.
