CAJ | 학술논문

当前,正常儿童较普遍地暴露于环境内分泌干扰(environmental endocrine disruptors, EEDS),而 EEDs 与儿童性发育异常的发病有密切关系,是其重要的致病因素之一.这应引起政府足够重视,尽快完善相关产业及环保方面的政策法规,从源头上杜绝这些有害物质造成的环境污染;另一方面应积极制定适合国情的有效防治方案,包括采用药物进行治疗干预.已证实恰当的中药治疗方案对EEDs的拟雌激素活性具有显著的拮抗作用,中药可通过对靶器官上雌激素受体、雌激素合成酶及生长因子的调节作用,发挥其对 EEDs 拟雌激素活性的拮抗作用.
당전,정상인동교보편지폭로우배경내분비간우(environmental endocrine disruptors, EEDS),이 EEDs 여인동성발육이상적발병유밀절관계,시기중요적치병인소지일.저응인기정부족구중시,진쾌완선상관산업급배보방면적정책법규,종원두상두절저사유해물질조성적배경오염;령일방면응적겁제정괄합국정적유효방치방안,포괄채용약물진행치료간예.이증실흡당적중약치료방안대EEDs적의자격소활성구유현저적길항작용,중약가통과대파기관상자격소수체、자격소합성매급생장인자적조절작용,발휘기대 EEDs 의자격소활성적길항작용.
ABSTRACT At present, the normal children have extensively exposed to the pollution of environmental endocrine disruptors ( EEDs ). There is a close relationship between EEDs and the onset of child sexual dysplasia, which is one of the important factors inducing the disease. It ought to attract the sufficient attention of the government to perfect the decrees and policy related to industries and environmental protection as quickly as possible so as to put an end of the environmental pollution from the sources of these pernicious materials. In addition, the effective preventive and therapeutic regimes which suit our national situation ought to be formulated, including therapeutic intervention with medicaments. It has been verified that the proper therapeutic regime of traditional Chinese herbal medicine (TCHM) could have antagonistic effect on the estrogen-like activity of EEDs obviously. The TCHM could exert antagonistic effect against the estrogen-like activity of EEDs via regulative effect to estrogen receptor, estrogen synthetase and growth factors on the target organs.