CAJ | 학술논문

目的:报道氨苯砜治疗15例对糖皮质激素耐药的成人原发性免疫性血小板减少症的临床疗效.方法:全部患者门诊治疗,给予氨苯砜口服50~100 mg/d 治疗12~104周,观察临床出血症状、血小板计数和血红蛋白值,并结合相关文献进行讨论.结果:平均治疗54.9(12~104)周后,1例获完全反应、7例有效、7例无效;5例血红蛋白值轻度下降.结论:氨苯砜是一种价格低廉且耐受性好的耐激素成人原发性免疫性血小板减少症的门诊治疗选择.
목적:보도안분풍치료15례대당피질격소내약적성인원발성면역성혈소판감소증적림상료효.방법:전부환자문진치료,급여안분풍구복50~100 mg/d 치료12~104주,관찰림상출혈증상、혈소판계수화혈홍단백치,병결합상관문헌진행토론.결과:평균치료54.9(12~104)주후,1례획완전반응、7례유효、7례무효;5례혈홍단백치경도하강.결론:안분풍시일충개격저렴차내수성호적내격소성인원발성면역성혈소판감소증적문진치료선택.
Objective: To report the clinical efficacy of dapsone in the treatment of 15 adult patients with glucocorticoid resistance of primary immune thrombocytopenia (ITP). Methods: All patients were treated in out-patient service with dapsone orally 50~100 mg/d for 12~104 weeks. The bleeding symptoms, platelet count and hemoglobin level were observed and discussed profoundly based on related literatures. Results: The average duration of treatment with dapsone was 54.9 (range 12~104) weeks;1 case achieved complete response, 7 cases achieved response, and 7 cases no response. 5 cases showed mild lower in hemoglobin level. Conclusion: Dapsone provides an inexpensive and well-tolerated alternative therapy for glucocorticoid resistance of primary ITP.