CAJ | 학술논문

目的探讨多药耐药基因1(Mdr1)、P-糖蛋白(P-glycoprotein,P-gp)和谷胱甘肽s-转移酶-π(glutathione s-transferase-π,Gst-π)在未接受化疗的肺腺癌患者中的表达及临床意义.方法回顾性分析128例原发性未化疗的肺腺癌患者的资料,采用免疫组化方法检测不同肺腺癌细胞中Mdr1、Pgp、Gst-π的表达,将检测结果分类统计并分析.结果随着肺腺癌分化程度的降低,Gst-π、P-gp、Mdr1的阳性率相应增高,提示预后不良.结论P-gp、Mdr1和Gst-π的表达在原发性肺腺癌的多药耐药中起重要作用,P-gp、Mdr1和Gst-π的联合检测有助于对预后的判断.
목적탐토다약내약기인1(Mdr1)、P-당단백(P-glycoprotein,P-gp)화곡광감태s-전이매-π(glutathione s-transferase-π,Gst-π)재미접수화료적폐선암환자중적표체급림상의의.방법회고성분석128례원발성미화료적폐선암환자적자료,채용면역조화방법검측불동폐선암세포중Mdr1、Pgp、Gst-π적표체,장검측결과분류통계병분석.결과수착폐선암분화정도적강저,Gst-π、P-gp、Mdr1적양성솔상응증고,제시예후불량.결론P-gp、Mdr1화Gst-π적표체재원발성폐선암적다약내약중기중요작용,P-gp、Mdr1화Gst-π적연합검측유조우대예후적판단.
Objective to analyse the relationship between Gst-π,Pgp,Mdr1 genes expres-sion and chemosensitivity of oxaliplatin in lung cancer cells. Methods Gst-π,Pgp and MrP1 mrna expression in lung cancer cell was detected by real-time polymerase chain reaction.(免疫组化)cytotoxicity of oxaliplatin in vitro was evaluated by Wst-8 colorimetric assay,and spearman biovariate cor-relation was applied for statistic analysis. Results With lung adenocarcinoma type. the lower credit organization Gst-π、Pgp、Mdr1mrna expression levels were positively,indicates poor prognosis. Conclusion:the Gst-π、Pgp、Mdr1 expression in adenocarcinoma lung cancer tissue could be used to predict che-mosensitivity of oxaliplatin,which will permit clinical physicians to select the best and individualized treatment for lung cancer patients.