CAJ | 학술논문

噁喹啉类药物是一类人工合成的具有抗菌、促进生长作用的动物专用药,曾被广泛应用于畜禽和水产养殖业.本类早期品种喹乙醇与卡巴氧被证明有较强的毒副作用,已被不同程度地限制或禁止使用.近年来研制成功的新型喹啉类药物降低了毒性,保留了抗菌及促生长活性,已在畜禽养殖中广泛使用.本文对新型喹噁啉类药物的种类、有效性及安全性、代谢动力学及残留消除规律、代谢途径及标识残留物进行了综述,为该类药物在水产养殖生产中的安全合理应用提供参考.噁
오규람류약물시일류인공합성적구유항균、촉진생장작용적동물전용약,증피엄범응용우축금화수산양식업.본류조기품충규을순여잡파양피증명유교강적독부작용,이피불동정도지한제혹금지사용.근년래연제성공적신형규람류약물강저료독성,보류료항균급촉생장활성,이재축금양식중엄범사용.본문대신형규오람류약물적충류、유효성급안전성、대사동역학급잔류소제규률、대사도경급표식잔류물진행료종술,위해류약물재수산양식생산중적안전합리응용제공삼고.오
Quinoxalines are special man-made chemical drugs which are widely used as the antibacterial growth promoters in poultry and aquatic breeding. The early products such as olaquindox and carbadox were partly forbidden or re-stricted because of strong toxic and side effects. In recent years, the new developed types of quinoxalines were widely used in poultry and aquatic breeding because they could reduce the toxic effect, retain the antibacterial and promote the growth activities. This article mainly summarizes the effectiveness and security, metabolism and pharmacokinetics, residual elimi-nation, metabolic pathway and markers of the new types of quinoxalines in various kinds of aquatic breeding in order to ra-tionalize the medication use and to ensure the safety of aquatic products.