CAJ | 학술논문

无创式直流电刺激中枢神经系统是现在用来减轻多种神经疾病症状的有效方法.为了探究静态直流电场对神经活动的作用机制,利用二维最小模型研究了其在静态直流电场作用下的动力学行为.通过分岔和相平面分析,发现3类神经元兴奋性对相同刺激的不同响应是由不同的峰放电起始动力过程造成的.从起始动力学的角度得到了静态直流电场对神经活动的影响,研究结果可以为无创式直流脑调制技术的应用和发展提供一定的理论指导.
무창식직류전자격중추신경계통시현재용래감경다충신경질병증상적유효방법.위료탐구정태직류전장대신경활동적작용궤제,이용이유최소모형연구료기재정태직류전장작용하적동역학행위.통과분차화상평면분석,발현3류신경원흥강성대상동자격적불동향응시유불동적봉방전기시동력과정조성적.종기시동역학적각도득도료정태직류전장대신경활동적영향,연구결과가이위무창식직류뇌조제기술적응용화발전제공일정적이론지도.
Nowadays,noninvasive stimulation of central nervous system is a promising therapeutic option to allevi-ate the symptoms of a number of neurological disorders. In order to explore the effects of static direct cur-rent(DC)electric field on neuronal activity,this paper investigated the dynamic behaviors of neuron under the effects of external static DC electric field using a two-dimensional minimal model. Through bifurcation and phase plane analysis,it can be found that different responses of three classes of neurons to the same stimulation are caused by different spike initiating dynamics. This paper illustrated the effects of static DC electric field on neuron activity from the point of the dynamics of action potential initiation. It can provide some theoretical guidance for the development and application of noninvasive DC brain modulation technology.