CAJ | 학술논문

目的探讨胃癌术中区域动脉灌注联合腹腔缓释化疗的临床效果.方法将80例进展期胃癌患者随机分为治疗组和对照组,治疗组于胃癌根治术中经肿瘤的主要供血动脉灌注含5-氟尿嘧啶和丝裂霉素的生理盐水灌注液,术毕将5-Fu 缓释剂植入肿瘤病灶区域、吻合口周围及淋巴回流区等区域.对照组术中不进行腹腔内干预性治疗.结果两组术后复发及转移率、3年和5年生存率的差异较大,有统计学意义,治疗组优于对照组.结论胃癌术中区域动脉灌注联合腹腔缓释化疗应用于临床,疗效肯定,具有推广应用价值.
목적탐토위암술중구역동맥관주연합복강완석화료적림상효과.방법장80례진전기위암환자수궤분위치료조화대조조,치료조우위암근치술중경종류적주요공혈동맥관주함5-불뇨밀정화사렬매소적생리염수관주액,술필장5-Fu 완석제식입종류병조구역、문합구주위급림파회류구등구역.대조조술중불진행복강내간예성치료.결과량조술후복발급전이솔、3년화5년생존솔적차이교대,유통계학의의,치료조우우대조조.결론위암술중구역동맥관주연합복강완석화료응용우림상,료효긍정,구유추엄응용개치.
Objective: To investigate the clinical effect of the regional arterial infusion and intraperitoneal sustained-release chemotherapy in gastric cancer. Methods: 80 cases of advanced gastric cancer patients were randomly divided into treatment and control groups. As treatment group, saline perfusion solutions containing 5-Fu and MMC were perfused through the main tumor feeding artery in gastric cancer radical resection, and the 5-Fu diluents were implanted in tumor lesion area, the anastomotic stoma vicinity and lymphatic recirculating zone slowly after surgery. The control group received no intervention in intra-abdominal treatment. Results:Postoperative recurrence rates, 3-year, 5-year survival rates have large difference with statistical significance between two treatments, the efficacy of treatment group is superior to that of control group. Conclusion:Regional arterial infusion and intraperitoneal sustained-release chemotherapy in gastric cancer surgery has effective clinical application, with popularization and application value.