CAJ | 학술논문

目的观察分析核苷类药物应用在乙型肝炎后肝硬化治疗中的临床疗效.方法从乙型肝炎后肝硬化患者中抽取90例,随机分为A、B、C 3组,分别使用不同的核苷类药物进行治疗,A组为拉米夫定,B组为阿德福韦酯,C组为恩替卡韦,对比观察其实验室指标变化.结果所有患者在治疗1年后其HBV病毒DNA载量明显低于治疗前,且C组患者的降低程度及HBeAg转阴率明显高于另外两组患者,不良反应明显低于另外两组,差异有统计学意义(P<0.05).结论对乙型肝炎后肝硬化患者使用核苷类药物进行治疗,能够有效降低患者体内病毒载量,其中恩替卡韦的临床治疗效果尤为突出,且不良反应较少,更为安全可靠,具有进一步推广应用的价值.
목적관찰분석핵감류약물응용재을형간염후간경화치료중적림상료효.방법종을형간염후간경화환자중추취90례,수궤분위A、B、C 3조,분별사용불동적핵감류약물진행치료,A조위랍미부정,B조위아덕복위지,C조위은체잡위,대비관찰기실험실지표변화.결과소유환자재치료1년후기HBV병독DNA재량명현저우치료전,차C조환자적강저정도급HBeAg전음솔명현고우령외량조환자,불량반응명현저우령외량조,차이유통계학의의(P<0.05).결론대을형간염후간경화환자사용핵감류약물진행치료,능구유효강저환자체내병독재량,기중은체잡위적림상치료효과우위돌출,차불량반응교소,경위안전가고,구유진일보추엄응용적개치.
Objective To observe the clinical analysis of nucleoside drugs used in treatment of liver cirrhosis after hepatitis B in. Methods From our hospital in patients with hepatitis B cirrhosis in the selected 90 cases, were randomly divided into A, B, C three groups, respectively, the use of nucleoside drugs of different treatment, A group for lamivudine, adefovir dipivoxil B group, C group, entecavir, compared to observe the changes of laboratory index. Results All the patients in the treatment of 1 years after the HBV-DNA virus load was obviously lower than that before treatment, and the patients in the C group decreased and HBeAg negative rate was significantly higher than that of the other two groups, less adverse reactions than the other two groups, the difference was statistically significant ( P < 0.05 ). Conclusion In patients with liver cirrhosis of hepatitis B after the use of nucleoside drugs for treatment, can effectively reduce the virus in patients with load, which well for clinical therapeutic effect of Cave is particularly prominent, and less adverse reactions, more safe and reliable, with further popularization and application value.