潍坊医学院学报
濰坊醫學院學報
유방의학원학보
JOURNAL OF WEIFANG MEDICAL COLLEGE
2012年
6期
404-407
,共4页
子宫内膜腺肿瘤%EZH2%E-cad
子宮內膜腺腫瘤%EZH2%E-cad
자궁내막선종류%EZH2%E-cad
Endometrioid adenocarcinoma%Enhancer of zeste homolog 2%Adenocarcinoma E-cadherin
目的探讨EZH2和上皮型钙粘蛋白(E-cad)在子宫内膜腺癌(EA)中的表达及意义.方法采用免疫组织化学法检测正常子宫内膜20例,子宫内膜单纯性增生20例,不典型增生33例和EA63例中EZH2和E-cad蛋白的表达.结果 EA中EZH2和E-cad的阳性表达率分别为82.5%(52/63)和28.6%(18/63),EZH2明显高于正常和各型增生内膜;而E-cad则明显低于正常子宫内膜(P均<0.05);EA中EZH2和E-cad的表达与临床分期、组织学分级和肌层浸润程度均有关,且两者表达呈负相关(rs=-0.474,P=0.000).结论 EZH2和E-cad的异常表达与EA的发生、发展密切相关.
目的探討EZH2和上皮型鈣粘蛋白(E-cad)在子宮內膜腺癌(EA)中的錶達及意義.方法採用免疫組織化學法檢測正常子宮內膜20例,子宮內膜單純性增生20例,不典型增生33例和EA63例中EZH2和E-cad蛋白的錶達.結果 EA中EZH2和E-cad的暘性錶達率分彆為82.5%(52/63)和28.6%(18/63),EZH2明顯高于正常和各型增生內膜;而E-cad則明顯低于正常子宮內膜(P均<0.05);EA中EZH2和E-cad的錶達與臨床分期、組織學分級和肌層浸潤程度均有關,且兩者錶達呈負相關(rs=-0.474,P=0.000).結論 EZH2和E-cad的異常錶達與EA的髮生、髮展密切相關.
목적탐토EZH2화상피형개점단백(E-cad)재자궁내막선암(EA)중적표체급의의.방법채용면역조직화학법검측정상자궁내막20례,자궁내막단순성증생20례,불전형증생33례화EA63례중EZH2화E-cad단백적표체.결과 EA중EZH2화E-cad적양성표체솔분별위82.5%(52/63)화28.6%(18/63),EZH2명현고우정상화각형증생내막;이E-cad칙명현저우정상자궁내막(P균<0.05);EA중EZH2화E-cad적표체여림상분기、조직학분급화기층침윤정도균유관,차량자표체정부상관(rs=-0.474,P=0.000).결론 EZH2화E-cad적이상표체여EA적발생、발전밀절상관.
Objective To study the expression and clinical significance of EZH 2 and E-cadherin(E-cad) in endometrioid adenocarcinoma tissue .Methods The expression levels of EZH2 and E-cad protein in endometrial adeno-carcinomas(n=63),endometrial atypical hyperplasia (n=33),endometrial hyperplasia(n=20) and normal endometri-um(n=20) were examined by immunohistochemistry .Results The positive expression rates of EZH2 and E-cad protein in endometrial adenocarcinoma were 82.5%(52/63),28.6%(18/63),The positive expression rate of EZH2 in the en-dometrial adenocarcinoma was significantly higher than that in the normal endometrium and endometrialhyperplasia ,while that of the E-cad in the adenocarcinoma was significantly lower than that in the normal endometrium (P<0.05).The positive expression of EZH2 and E-cad was related to histological grade ,FIGO stage and depth of invasion(P<0.05). The expression of EZH2 protein was negatively related to that of E-cad (rs=-0.474,P=0.000).Conclusion The abnormal expression of EZH2 and E-cad protein is associated with the pathogenesis and progression of endometrioid ade-nocarcinoma.
