CAJ | 학술논문

目的探讨低分子肝素(LMWH)与肠溶阿司匹林(ASP)序贯应用预防妇科恶性肿瘤术后深静脉血栓(DVT)形成的疗效.方法选择2003年1月~2011年12月我院妇科恶性肿瘤大型手术652例,其中对照组共221例单独应用肠溶阿司匹林(ASP),试验组共431例序贯应用低分子肝素(LMWH)与肠溶ASP,以D-二聚体测定、临床表现和彩超(CDFI)检查结果,统计学分析比较不同的用药方法预防术后DVT形成的效果.结果对照组确诊有症状型DVT11例,发病率4.98%;试验组确诊有症状型DVT6例,发病率1.39%,两组间差异有极显著意义(P<0.01).两组病例均无术后出血等用药并发症.结论 LMWH与肠溶ASP序贯应用预防妇科恶性肿瘤术后DVT效果满意,安全方便,并发症少,值得临床推广应用.
목적탐토저분자간소(LMWH)여장용아사필림(ASP)서관응용예방부과악성종류술후심정맥혈전(DVT)형성적료효.방법선택2003년1월~2011년12월아원부과악성종류대형수술652례,기중대조조공221례단독응용장용아사필림(ASP),시험조공431례서관응용저분자간소(LMWH)여장용ASP,이D-이취체측정、림상표현화채초(CDFI)검사결과,통계학분석비교불동적용약방법예방술후DVT형성적효과.결과대조조학진유증상형DVT11례,발병솔4.98%;시험조학진유증상형DVT6례,발병솔1.39%,량조간차이유겁현저의의(P<0.01).량조병례균무술후출혈등용약병발증.결론 LMWH여장용ASP서관응용예방부과악성종류술후DVT효과만의,안전방편,병발증소,치득림상추엄응용.
Objective To investigate the efficacy of the sequential application of low molecular weight hepa-rin(LMWH) and enteric-coated aspirin(ASP) in preventing postoperative deep venous thrombosis (DVT) after gyneco-logic malignancy surgery.Methods Six hundred and fifty-two cases who received major gynecological surgery of malig-nancies from January 2003 to December 2011 in the author's hospital were chosen.The control group with a total number of 221 cases used enteric-coated aspirin alone and the experimental group with a total number of 431 cases were sequen-tially applied with both the LMWH and the enteric-coated ASP.Through the examination of D-Dimer,the clinical mani-festations and color doppler flow imaging (CDFI),the final results of the effect to prevent postoperative DVT were statisti-cally compared.Results It was found that there were 11 cases who were diagnosed of the symptoms of DVT in the con-trol group and the incidence rate was 4.98%,while the experimental group was confirmed with only 6 DVT cases and the incidence rate was merely 1.39%.It can be seen that the difference between the two groups was very significant (P<0. 01).There was no postoperative bleeding medication complications of either group .Conclusion The sequential applica-tion of LMWH and enteric ASP in preventing postoperative DVT after gynecologic malignancy surgeries has satisfactory results with safety,convenience and fewer complications ,which was worthy of clinical application .