CAJ | 학술논문

目的评价2型糖尿病患者焦虑情绪与糖脂代谢紊乱的相关性.方法初诊2型糖尿病患者89例,采用Zung焦虑自评量表(SAS)进行评分,依据评分结果分为2型糖尿病合并焦虑情绪组(DA)37例和2型糖尿病非焦虑情绪组(NDA)52例,对照组为同期健康体检者(NC)33例.记录受试者一般资料,测定空腹血糖(FPG)、糖负荷后2h血糖(2hPG)、糖化血红蛋白(HbA1c)、血脂和高敏C反应蛋白(hs-CRP).结果与NDA组比较,DA组的心率、FPG、2hPG、HbA1c、TG、LDL-C及hs-CRP水平均显著升高(P均<0.05);相关分析显示,2型糖尿病患者SAS 评分与心率、FPG、2hPG、HbA1c、TG、LDL-C及hs-CRP水平呈正相关;多元逐步回归显示,2hPG、HbA1c、LDL-C及hs-CRP水平对2型糖尿病焦虑情绪具有显著性影响(P均<0.05).结论2型糖尿病焦虑情绪与糖脂代谢紊乱、慢性炎症反应密切相关,其中2hPG,HbA1c,LDL-C及hs-CRP可能参与了2型糖尿病患者焦虑情绪的发生.
목적평개2형당뇨병환자초필정서여당지대사문란적상관성.방법초진2형당뇨병환자89례,채용Zung초필자평량표(SAS)진행평분,의거평분결과분위2형당뇨병합병초필정서조(DA)37례화2형당뇨병비초필정서조(NDA)52례,대조조위동기건강체검자(NC)33례.기록수시자일반자료,측정공복혈당(FPG)、당부하후2h혈당(2hPG)、당화혈홍단백(HbA1c)、혈지화고민C반응단백(hs-CRP).결과여NDA조비교,DA조적심솔、FPG、2hPG、HbA1c、TG、LDL-C급hs-CRP수평균현저승고(P균<0.05);상관분석현시,2형당뇨병환자SAS 평분여심솔、FPG、2hPG、HbA1c、TG、LDL-C급hs-CRP수평정정상관;다원축보회귀현시,2hPG、HbA1c、LDL-C급hs-CRP수평대2형당뇨병초필정서구유현저성영향(P균<0.05).결론2형당뇨병초필정서여당지대사문란、만성염증반응밀절상관,기중2hPG,HbA1c,LDL-C급hs-CRP가능삼여료2형당뇨병환자초필정서적발생.
Objective To evaluate the correlation of glucolipid metabolic disorders and anxiety in type 2 di-abetes.Methods Based on Zung self-rating anxiety scale(SAS),89 newly diagnosed type 2 diabetes patients were di-vided into two groups,37 cases accompanied with anxiety in group 1(DA) and 52 cases without anxiety in group 2 (NDA).33 healthy people were chosen as control group (NC) for the same period.Glycosylated hemoglobin,fasting plasma glucose,2h plasma glucose,blood lipid analysis and hs-CRP were measured and general informations were recor-ded.Results Compared with NDA group,heart rate,FPG,2hPG,HbA1c,TG,LDL-C and hs-CRP levels of DA group were significantly increased(P<0.05).SAS scores were positively correlated with heart rate ,FPG,2hPG,HbA1c,TG, LDL-C and hs-CRP levels.Multiple stepwise regression analysis showed that 2hPG HbA1c,LDL-C and hs-CRP levels had a significant impact on anxiety mood of type 2 diabetes patients(P<0.05).Conclusion Anxiety mood and glu-colipid metabolic disorders,chronic inflammation response were closely related in type 2 diabetes,especially,2hPG, HbA1c,LDL-C and hs-CRP,may be involved in the occurrence of type 2 diabetes anxiety.