CAJ | 학술논문

目的观察射频热疗联合腹腔顺铂灌注化疗对胃癌腹腔积液患者的临床疗效.方法比较54例应用射频热疗联合顺铂治疗后的胃癌腹腔积液患者与30例未应用射频热疗仅应用顺铂灌注化疗后的胃癌腹腔积液患者的临床疗效.结果治疗组与对照组的有效率分别为40.74%,26.67%,差异有显著性(P<0.05).毒副反应较轻,主要为轻、中度的骨髓抑制及消化道反应,偶有发热,治疗组与对照组差异无显著性(P>0.05).随访显示,热疗组:随访时间最长为24个月,有效病例的中位生存时间8.8个月.非热疗组:随访时间最长为24个月,有效病例的中位生存时间5.3个月.结论射频透热治疗联合腹腔顺铂灌注化疗治疗胃癌腹腔积液比单纯腹腔灌注顺铂化疗疗效高,是恶性腹腔积液安全、有效的治疗手段.
목적관찰사빈열료연합복강순박관주화료대위암복강적액환자적림상료효.방법비교54례응용사빈열료연합순박치료후적위암복강적액환자여30례미응용사빈열료부응용순박관주화료후적위암복강적액환자적림상료효.결과치료조여대조조적유효솔분별위40.74%,26.67%,차이유현저성(P<0.05).독부반응교경,주요위경、중도적골수억제급소화도반응,우유발열,치료조여대조조차이무현저성(P>0.05).수방현시,열료조:수방시간최장위24개월,유효병례적중위생존시간8.8개월.비열료조:수방시간최장위24개월,유효병례적중위생존시간5.3개월.결론사빈투열치료연합복강순박관주화료치료위암복강적액비단순복강관주순박화료료효고,시악성복강적액안전、유효적치료수단.
Objective To explore the clinical significance of radio frequency heat treatment combined with celiac cisplatin perfusion chemotherapy for gastric cancer peritoneal effusion .Methods The clinical significance was compared of 54 applications treated by radio frequency hyperthermia combined with cisplatin perfusion chemotherapy and 30 applications treated by cisplatin perfusion chemotherapy only with malignant ascites in patients with gastric cancer . Results The efficient of the treatment group and the control group were 40.74% and 26.67% respectively,there was significant difference(P<0.05).Side reactions were light,mainly for the light or moderate bone marrow suppression , gastrointestinal reaction and occasional fever .The treatment group and the control group had no significant difference (P>0.05).Follow-up showed that hyperthermia group:follow-up time of effective cases up to 24 months,the median sur-vival time was 8.8 months.Non-hyperthermia group:Follow-up of effective cases time up to 24 months,the median sur-vival time was 5.3 months.Conclusion Radio frequency hyperthermia diathermy therapy combined with celiac cispaltin perfusion chemotherapy has a high curative effect to stomach cancer patients with malignant ascites than cisplatin perfu -sion chemotherapy alone,which is a malignant ascites safe ,effective treatment.