CAJ | 학술논문

目的探讨HMGB1在乳腺癌及乳腺良性病变中的表达及意义.方法采用免疫组织化学方法检测乳腺浸润性导管癌、乳腺导管内原位癌和乳腺纤维瘤组织中HMGB1蛋白的表达,分析HMGB1的表达与乳腺癌临床病理特征之间的关系.结果浸润性导管癌中HMGB1蛋白呈阳性表达,细胞核染色呈黄色或棕褐色颗粒状,细胞质也有微弱着色;导管内原位癌组织中HMGB1呈阳性表达;而乳腺纤维瘤组织中HMGB1蛋白不表达或弱表达.结论 HMGB1在乳腺癌的发生发展中起重要作用,对预测乳腺癌发展及预后评价有重要的意义.
목적탐토HMGB1재유선암급유선량성병변중적표체급의의.방법채용면역조직화학방법검측유선침윤성도관암、유선도관내원위암화유선섬유류조직중HMGB1단백적표체,분석HMGB1적표체여유선암림상병리특정지간적관계.결과침윤성도관암중HMGB1단백정양성표체,세포핵염색정황색혹종갈색과립상,세포질야유미약착색;도관내원위암조직중HMGB1정양성표체;이유선섬유류조직중HMGB1단백불표체혹약표체.결론 HMGB1재유선암적발생발전중기중요작용,대예측유선암발전급예후평개유중요적의의.
Objective To investigate expression and clinical significance of HMGB 1 in breast cancer and benign diseases of breast .Methods The expression of HMGB1 protein in invasive ductal carcinoma ,intraductal carcino-ma in situ and mammary gland fibroma was detected by immunohistochemical SP method .The correlation between HMGB1 expression and clinicopathological features in breast cancer was analyzed .Results In invasive ductal carcino-ma,HMGB1 protein was positive expressed .The colouration of nucleus was granular in yellow or sepia colour ,and the cy-toplasmic colouration was dyed slight .HMGB1 protein was positive expressed in intraductal carcinoma in situ .But in mammary gland fibroma HMGB1 expressed none or infirmly.Conclusion HMGB1 plays an important role in the occur-rence and progress in breast cancer and has important significance in forecasting the progress and estimating the progno -sis of breast cancer.