CAJ | 학술논문

目的观察左西孟旦对急性心肌梗死后急性左心衰竭患者心功能及血流动力学的影响.方法选择自2011年1月~2012年7月到潍坊市中医院急救中心住院的急性心肌梗死伴急性左心衰竭患者42例,年龄66~82岁,随机分为治疗组(22例,左西孟旦组)和对照组(20例,多巴酚丁胺组).治疗组初始左西孟旦负荷量12μg /kg,注射时间10min,随即以0.1μg/(kg? min)静滴1h后增加到0.2μg/(kg? min)并持续23h;对照组给予多巴酚丁胺2.5μg/(kg? min),1h后增加到5μg/(kg? min),并持续静滴47h.在治疗前、治疗48h分别测定LVEF,SV,BNP.结果治疗48h后两组患者LVEF,SV均较治疗前明显升高(P<0.05),两组患者BNP水平较治疗前明显降低(P<0.05).治疗48h后,治疗组LVEF,SV较对照组明显升高,BNP较对照组明显降低(P<0.05).结论左西孟旦能有效改善急性心肌梗死后急性左心衰竭患者的血流动力学指标,改善心功能.
목적관찰좌서맹단대급성심기경사후급성좌심쇠갈환자심공능급혈류동역학적영향.방법선택자2011년1월~2012년7월도유방시중의원급구중심주원적급성심기경사반급성좌심쇠갈환자42례,년령66~82세,수궤분위치료조(22례,좌서맹단조)화대조조(20례,다파분정알조).치료조초시좌서맹단부하량12μg /kg,주사시간10min,수즉이0.1μg/(kg? min)정적1h후증가도0.2μg/(kg? min)병지속23h;대조조급여다파분정알2.5μg/(kg? min),1h후증가도5μg/(kg? min),병지속정적47h.재치료전、치료48h분별측정LVEF,SV,BNP.결과치료48h후량조환자LVEF,SV균교치료전명현승고(P<0.05),량조환자BNP수평교치료전명현강저(P<0.05).치료48h후,치료조LVEF,SV교대조조명현승고,BNP교대조조명현강저(P<0.05).결론좌서맹단능유효개선급성심기경사후급성좌심쇠갈환자적혈류동역학지표,개선심공능.
Objective To evaluate the effects of levosimendan on hemodynamic performance in patients with acute left heart fail -ure due to acute myocardial infarction.Methods Forty-two patients were randomly divided into 2 groups.Control group (20cases,dobu-tamine) and Trial group(22 cases,levosimendan).Trial group was given an initial loading dose of levosimendan of 12μg/kg,infused over 10 min,followed by a infusion of 0.1μg/(kg? min) for 1h and 0.1μg/(kg? min) for 23h.Control group was given dobutamine infused for 1h at an initial dose of 2.5μg/(kg? min) and for 47h at an continuous dose of 5μg/(kg? min) without a loading dose.BNP testing,echocar-diography measurement in LVEF and SV of both group were taken before and after treatment medication .Results The plasma BNP level of two groups were obviously decreased after treatment (P<0.05);LVEF and SV of two groups were obviously increased after treatment (P<0. 05).After treatment the BNP level of trial group was obviously lower than control group (P<0.05),and LVEF and SV were obviously higher than control group(P<0.05).Conclusion Levosimendan could improve hemodynamic performance in patients with acute left heart failure due to acute myocardial infarction.