CAJ | 학술논문

目的探讨血管紧张素转换酶(ACE)基因多态性与老年充血性心力衰竭(CHF)患者心室重构的相关性.方法选取50例正常对照组和104例老年心衰患者,所有受试者进行ACE基因分型,用多聚酶链反应测定ACE基因多态性;超声心动图测量左室舒张末期内径(LVEDD)、左心室舒张末期容积(LVEDV)和左心室射血分数(LVEF).结果①老年CHF组DD基因型较ID型、II型患者LVEDD、LVEDV明显增高,而LVEF明显降低,差异具有统计学意义,P<0.01.②老年CHF伴左心室肥厚组,DD基因型频率及D等位基因频率较老年CHF不伴左室肥厚组明显增高,P<0.01.结论 ACE基因型与老年心衰患者心室重构相关,DD基因型及D等位基因的老年心衰患者易出现心室重构.
목적탐토혈관긴장소전환매(ACE)기인다태성여노년충혈성심력쇠갈(CHF)환자심실중구적상관성.방법선취50례정상대조조화104례노년심쇠환자,소유수시자진행ACE기인분형,용다취매련반응측정ACE기인다태성;초성심동도측량좌실서장말기내경(LVEDD)、좌심실서장말기용적(LVEDV)화좌심실사혈분수(LVEF).결과①노년CHF조DD기인형교ID형、II형환자LVEDD、LVEDV명현증고,이LVEF명현강저,차이구유통계학의의,P<0.01.②노년CHF반좌심실비후조,DD기인형빈솔급D등위기인빈솔교노년CHF불반좌실비후조명현증고,P<0.01.결론 ACE기인형여노년심쇠환자심실중구상관,DD기인형급D등위기인적노년심쇠환자역출현심실중구.
Objective To investigate the relationship between angiotensin-converting enzyme(ACE) gene insertion/deletion(I/D) polymorphism and congestive heart failure (CHF) in elderly patients.Methods Choose 50 cases as normal control group and 104 cases as CHF group elderly.The I/D polymorphism of ACE gene was studied using polymerase chain reaction (PCR) and restriction fragment length polymorphism(RFLP).With Doppler ultra-sonic apparatus,the size of left ventricular diastasis diameter (LVEDD),left ventricular diastasis volume(LVEDV) and left ventricular ejection fraction (LVEF) in 104 patients were measured,and the results were analysed.Results ①In CHF group,LVEDD and LVEDV were highest in DD genotype among three genotypes ,while LVEF was lowest(P<0.01).②The frequencies of the DD genotype and D allele in CHF with left ventricular hypertrophy (LVH) group were significantly higher than those in CHF without LVH group(P<0.01).Conclusion The ACE genotypes have correlation with the occurrence of CHF in elderly patients ,and who with DD genotype or D allele are easier to develop into LVH .