CAJ | 학술논문

背景:颌骨缺损时形态的修复不仅要考虑形态也要考虑咬合关系能否建立.目的:对近年来骨组织工程中种子细胞应用于颌骨缺损修复治疗的研究现状做一综述.方法:以Bone tissue engineering, seeded cel s,Osteogenic Differentiation为英文检索词,以骨组织工程,种子细胞,成骨分化,骨缺损修复为中文检索词,检索1994年1月至2011年4月 PubMed数据库和CNKI数据库相关文献.阅读标题和进行初筛,排除因研究目的与此文无关及内容重复性文献,共保留58篇文献进行综述.结果与结论:综合分析各种种子细胞应用于骨组织工程的研究现状,认为骨髓间充质干细胞研究最多,而脐血间充质干细胞和脐带间充质干细胞的研究因其能克服骨髓间充质干细胞应用的诸多缺点故也较为热门.胚胎干细胞存在伦理学上的困境,若能够有所突破,仍有望成为重要的颌骨缺损时骨组织工程的种子细胞之一.基因修饰的种子细胞能增强骨组织工程种子细胞的增殖能力和定向成骨分化的能力.但基因工程技术仍有待提高,其安全性和有效性仍有待商榷.
배경:합골결손시형태적수복불부요고필형태야요고필교합관계능부건립.목적:대근년래골조직공정중충자세포응용우합골결손수복치료적연구현상주일종술.방법:이Bone tissue engineering, seeded cel s,Osteogenic Differentiation위영문검색사,이골조직공정,충자세포,성골분화,골결손수복위중문검색사,검색1994년1월지2011년4월 PubMed수거고화CNKI수거고상관문헌.열독표제화진행초사,배제인연구목적여차문무관급내용중복성문헌,공보류58편문헌진행종술.결과여결론:종합분석각충충자세포응용우골조직공정적연구현상,인위골수간충질간세포연구최다,이제혈간충질간세포화제대간충질간세포적연구인기능극복골수간충질간세포응용적제다결점고야교위열문.배태간세포존재윤리학상적곤경,약능구유소돌파,잉유망성위중요적합골결손시골조직공정적충자세포지일.기인수식적충자세포능증강골조직공정충자세포적증식능력화정향성골분화적능력.단기인공정기술잉유대제고,기안전성화유효성잉유대상각.
BACKGROUND:The morphology as wel as the establishment of occlusal relationship should be considered during the construction of jawbone defects. OBJECTIVE:To summarize the research status of seeded cel s of bone tissue engineering applied to the treatment of jawbone defects in recent years. METHODS:A computer-based online search was conducted in PubMed database and CNKI database for the relate articles published from June 1994 to April 2011 with the key words“bone tissue engineering, seeded cel s, osteogenic differentiation”in Chinese and English. The irrelevant or repetitive articles were eliminated by reading the titles and abstracts. A total of 58 articles were selected to review. RESULTS AND CONCLUSION:This paper has comprehensively analyzed the current research of various seeded cel s used in bone tissue engineering, bone marrow stromal stem cel s are most studied, and the research on umbilical cord blood mesenchymal stem cel s and umbilical cord mescenchymal stem cel s is also popular as scholars can overcome the application disadvantages of mesenchymal stem cel s. Embryonic stem cel s are expected to become the important seeded cel s in bone tissue engineering for repair of jawbone defects if there are no ethical problems. Genetical y modified seed cel s can enhance the proliferation and directed osteogenic differentiation capacity of seeded cel s in bone tissue engineering. But genetic engineering technique is stil needed to be improved, and its safety and effectiveness need further discussion.