CAJ | 학술논문

背景:干细胞局部移植可治疗神经系统疾病.目的:观察脐血干细胞移植联合使用鼠神经生长因子及物理康复治疗小儿脑性瘫痪的临床效果.方法:将90例小儿脑性瘫痪患儿根据是否接受干细胞治疗分为3组:脐血干细胞治疗组采用脐血干细胞+鼠神经生长因子+物理康复治疗,常规治疗组采用鼠神经生长因子+物理康复治疗,对照组未行有效治疗.结果与结论:3组患儿入组前粗大运动功能测试量表各能区分值差异无显著性意义(P>0.05).治疗后3个月,脐血干细胞治疗组及常规治疗组粗大运动功能测试量表各能区中A、B、D能区分值较治疗前提高(P<0.05),且脐血干细胞治疗组A、B能区分值均明显高于常规治疗组(P <0.05),对照组粗大运动功能测试量表各能区分值无变化(P >0.05).表明脐血干细胞移植联合使用鼠神经生长因子、物理康复治疗治疗小儿脑瘫疗效优于鼠神经生长因子联合物理康复疗法.
배경:간세포국부이식가치료신경계통질병.목적:관찰제혈간세포이식연합사용서신경생장인자급물리강복치료소인뇌성탄탄적림상효과.방법:장90례소인뇌성탄탄환인근거시부접수간세포치료분위3조:제혈간세포치료조채용제혈간세포+서신경생장인자+물리강복치료,상규치료조채용서신경생장인자+물리강복치료,대조조미행유효치료.결과여결론:3조환인입조전조대운동공능측시량표각능구분치차이무현저성의의(P>0.05).치료후3개월,제혈간세포치료조급상규치료조조대운동공능측시량표각능구중A、B、D능구분치교치료전제고(P<0.05),차제혈간세포치료조A、B능구분치균명현고우상규치료조(P <0.05),대조조조대운동공능측시량표각능구분치무변화(P >0.05).표명제혈간세포이식연합사용서신경생장인자、물리강복치료치료소인뇌탄료효우우서신경생장인자연합물리강복요법.
BACKGROUND:Umbilical cord blood stem cel transplantation is an optimal therapeutic method of nervous system diseases. OBJECTIVE:To investigate the clinical efficacy of umbilical cord blood stem cel transplantation combined with mouse neural stem cel application and physical rehabilitation therapy for infantile cerebral palsy. METHODS:90 patients with cerebral palsy were randomly and evenly divided into three groups:umbilical cord blood stem cel s group (umbilical cord blood mesenchymal stem cel s+mouse neural growth factor+physical rehabilitation therapy), routine treatment group (mouse neural growth factor+physical rehabilitation therapy) and control group (no effective treatment). RESULTS AND CONCLUSION:Prior to treatment, there was no significant difference in gross motor function measure (GMFM) scores of each functional item among three groups (P>0.05). Compared with prior to treatment, at 3 months after treatment, the GMFM scores of A, B, D items were significantly increased in the umbilical cord blood stem cel s group and routine treatment group (P<0.05);GMFM scores of A, B functional items were significantly higher in the umbilical cord blood stem cel s group than in the routine treatment group (P<0.05);there was no significant difference in GMFM scores of each functional item in the control group (P>0.05). These results showed that umbilical cord blood mesenchymal stem cel transplantation combined with mouse neural stem cel application and physical rehabilitation therapy exhibits better curative effects in treatment of infantile cerebral palsy than mouse neural growth factor application combined with physical rehabilitation therapy.