中国组织工程研究
中國組織工程研究
중국조직공정연구
Journal of Clinical Rehabilitative Tissue Engineering Research
2012年
42期
7945-7950
,共6页
谢庆云%魏萌%张波%康夏%刘希麟%刘金标
謝慶雲%魏萌%張波%康夏%劉希麟%劉金標
사경운%위맹%장파%강하%류희린%류금표
类风湿关节炎%白细胞介素17%C-反应蛋白%红细胞沉降率%病情活动性%细胞因子%炎症反应%关节软骨%慢性滑膜炎%血管炎
類風濕關節炎%白細胞介素17%C-反應蛋白%紅細胞沉降率%病情活動性%細胞因子%炎癥反應%關節軟骨%慢性滑膜炎%血管炎
류풍습관절염%백세포개소17%C-반응단백%홍세포침강솔%병정활동성%세포인자%염증반응%관절연골%만성활막염%혈관염
背景:由滑膜细胞、单核/巨噬细胞以及淋巴细胞等产生的炎性细胞因子在类风湿关节炎的发病中发挥着重要作用.白细胞介素17是近年来发现的一个炎性细胞因子,与很多自身免疫性疾病有关.目的:观察类风湿关节炎患者血清中辅助性T细胞17相关的白细胞介素17水平及其与红细胞沉降率、C-反应蛋白、疾病活动性的相关性.方法:纳入2008年1月至2009年12月在解放军成都军区总医院就诊的符合1987年美国风湿病协会修订的类风湿关节炎分类标准的类风湿关节炎患者79例作为病例组,同时选取同时期性别、年龄与病例组相匹配的50名健康体检者作为对照组.根据28处关节疾病活动性评分指数将病例组分为活动组49例和稳定组30例.结果与结论:ELISA检测结果显示,类风湿关节炎患者血清白细胞介素17水平明显高于对照组(P <0.01),且活动期患者的白细胞介素17水平高于稳定期患者(P <0.01).Pearson相关分析结果显示,活动期类风湿关节炎患者血清中白细胞介素17水平与红细胞沉降率、C-反应蛋白、28处关节疾病活动性评分指数均呈正相关(r=0.459,0.379,0.455;P <0.05).说明白细胞介素17参与了类风湿关节炎的炎症反应,与红细胞沉降率、C-反应蛋白、28处关节疾病活动性评分指数等同样能反映病情的活动性.
揹景:由滑膜細胞、單覈/巨噬細胞以及淋巴細胞等產生的炎性細胞因子在類風濕關節炎的髮病中髮揮著重要作用.白細胞介素17是近年來髮現的一箇炎性細胞因子,與很多自身免疫性疾病有關.目的:觀察類風濕關節炎患者血清中輔助性T細胞17相關的白細胞介素17水平及其與紅細胞沉降率、C-反應蛋白、疾病活動性的相關性.方法:納入2008年1月至2009年12月在解放軍成都軍區總醫院就診的符閤1987年美國風濕病協會脩訂的類風濕關節炎分類標準的類風濕關節炎患者79例作為病例組,同時選取同時期性彆、年齡與病例組相匹配的50名健康體檢者作為對照組.根據28處關節疾病活動性評分指數將病例組分為活動組49例和穩定組30例.結果與結論:ELISA檢測結果顯示,類風濕關節炎患者血清白細胞介素17水平明顯高于對照組(P <0.01),且活動期患者的白細胞介素17水平高于穩定期患者(P <0.01).Pearson相關分析結果顯示,活動期類風濕關節炎患者血清中白細胞介素17水平與紅細胞沉降率、C-反應蛋白、28處關節疾病活動性評分指數均呈正相關(r=0.459,0.379,0.455;P <0.05).說明白細胞介素17參與瞭類風濕關節炎的炎癥反應,與紅細胞沉降率、C-反應蛋白、28處關節疾病活動性評分指數等同樣能反映病情的活動性.
배경:유활막세포、단핵/거서세포이급림파세포등산생적염성세포인자재류풍습관절염적발병중발휘착중요작용.백세포개소17시근년래발현적일개염성세포인자,여흔다자신면역성질병유관.목적:관찰류풍습관절염환자혈청중보조성T세포17상관적백세포개소17수평급기여홍세포침강솔、C-반응단백、질병활동성적상관성.방법:납입2008년1월지2009년12월재해방군성도군구총의원취진적부합1987년미국풍습병협회수정적류풍습관절염분류표준적류풍습관절염환자79례작위병례조,동시선취동시기성별、년령여병례조상필배적50명건강체검자작위대조조.근거28처관절질병활동성평분지수장병례조분위활동조49례화은정조30례.결과여결론:ELISA검측결과현시,류풍습관절염환자혈청백세포개소17수평명현고우대조조(P <0.01),차활동기환자적백세포개소17수평고우은정기환자(P <0.01).Pearson상관분석결과현시,활동기류풍습관절염환자혈청중백세포개소17수평여홍세포침강솔、C-반응단백、28처관절질병활동성평분지수균정정상관(r=0.459,0.379,0.455;P <0.05).설명백세포개소17삼여료류풍습관절염적염증반응,여홍세포침강솔、C-반응단백、28처관절질병활동성평분지수등동양능반영병정적활동성.
BACKGROUND:The inflammatory cytokines, produced by synovial cel s, monocytes/macrophages and lymphocytes, play a major role in the pathogenesis of rheumatoid arthritis. Interleukin-17, a recently found inflammatory cytokine, associates with many autoimmune diseases. OBJECTIVE:To investigate the correlation between the levels of interleukin 17 related to Th17 cel s in serum of rheumatoid arthritis patients and other laboratory markers such as erythrocyte sedimentation rate, C reactive protein and disease activity. METHODS:Seventy-nine patients with rheumatoid arthritis which line with classification criteria of rheumatoid arthritis revised by American Rheumatism Association in 1987 were selected from General Hospital of Chengdu Military Command (2008-01/2009-12), and the 79 patients were regarded as the experimental group;meanwhile, 50 healthy subjects who had the same gender and age with the experimental group were regarded as the control group. The experimental group was divided into activity group (n=49) and stable group (n=30) according the disease activity score in 28 joints. RESULTS AND CONCLUSION:Enzyme linked immunosorbent assay results showed that the level of interleukin 17 in peripheral blood of rheumatoid arthritis patients was significantly higher than that in the control group (P<0.01), and the level of interleukin 17 in the activity group was higher than that in the stable group (P<0.01). Pearson correlation analysis showed there was a positive correlation between interleukin 17 and erythrocyte sedimentation rate, C reactive protein, disease activity score in 28 joints in rheumatoid arthritis patients with active disease (r=0.459, 0.379, 0.455;P<0.05). Interleukin-17 was involved in the inflammatory response of rheumatoid arthritis, and it could also reflect disease activity just as the erythrocyte sedimentation rate and C-reactive protein, 28 joint disease activity score index do.