CAJ | 학술논문

背景:近年来,许多学者纷纷通过构建和研究动物模型来模仿慢性支气管炎的病理特征,以进一步阐明其发病的遗传背景、诱发因素、发病机制.目的:对国内外诱导慢性支气管炎动物模型的现状及新进展作一综述.方法:应用计算机检索CNKI和Pubmed数据库中1999年1月至2011年10月关于慢性支气管炎动物模型的文章,在标题和中以“慢性支气管炎,动物,模型”或“chronic bronchitis,animals,model”为检索词进行检索.最终选择24篇文献进行综述.结果与结论:建立慢性支气管炎动物模型的方法主要有化学药物法、细菌感染法、被动吸烟法和复合方法等,每种方法各有其优缺点,目前尚无一种公认最理想的方法,还有待于进一步的研究和探索.
배경:근년래,허다학자분분통과구건화연구동물모형래모방만성지기관염적병리특정,이진일보천명기발병적유전배경、유발인소、발병궤제.목적:대국내외유도만성지기관염동물모형적현상급신진전작일종술.방법:응용계산궤검색CNKI화Pubmed수거고중1999년1월지2011년10월관우만성지기관염동물모형적문장,재표제화중이“만성지기관염,동물,모형”혹“chronic bronchitis,animals,model”위검색사진행검색.최종선택24편문헌진행종술.결과여결론:건립만성지기관염동물모형적방법주요유화학약물법、세균감염법、피동흡연법화복합방법등,매충방법각유기우결점,목전상무일충공인최이상적방법,환유대우진일보적연구화탐색.
BACKGROUND:In recent years, many scholars have done a lot of studies on pathological features of chronic bronchitis based on animal model construction to further elucidate the genetic background of the incidence, predisposing factors, and pathogenesis. OBJECTIVE:To summarize the investigative situation and progression about animal models of chronic bronchitis at home and abroad. METHODS:Databases of CNKI and PubMed (1999-01/2011-10) were searched to retrieve the related articles about animal models of chronic bronchitis using the key words of“chronic bronchitis, animals, model”in Chinese and English, respectively. Final y, 24 articles were included in result analysis. RESULTS AND CONCLUSION:The methods to construct an animal model of chronic bronchitis mainly include chemical medicine, bacterial infection, passive smoking and composite method. Each method has its own advantages and disadvantages. Up to now, there is no recognized ideal method that needs further studies.