CAJ | 학술논문

背景:白细胞介素1是强直性脊柱炎易感基因之一,其多态性与疾病易感性相关,不同人群的研究结果不尽相同.目的:分析中国湖北汉族人群中白细胞介素1受体拮抗剂基因多态性与强直性脊柱炎的相关性.方法:自140名强直性脊柱炎患者及130名健康对照者外周血中提取DNA,采用PCR方法检测白细胞介素1受体拮抗剂基因第二内含子VNTR复等位基因多态性.所有受试者均为3代或3代以上居住于湖北的汉族人.结果与结论:强直性脊柱炎患者中白细胞介素1受体拮抗剂基因*2等位基因频率显著高于健康对照者(P<0.05).提示强直性脊柱炎与白细胞介素1受体拮抗剂基因*2等位基因相关联.
배경:백세포개소1시강직성척주염역감기인지일,기다태성여질병역감성상관,불동인군적연구결과불진상동.목적:분석중국호북한족인군중백세포개소1수체길항제기인다태성여강직성척주염적상관성.방법:자140명강직성척주염환자급130명건강대조자외주혈중제취DNA,채용PCR방법검측백세포개소1수체길항제기인제이내함자VNTR복등위기인다태성.소유수시자균위3대혹3대이상거주우호북적한족인.결과여결론:강직성척주염환자중백세포개소1수체길항제기인*2등위기인빈솔현저고우건강대조자(P<0.05).제시강직성척주염여백세포개소1수체길항제기인*2등위기인상관련.
BACKGROUND:Interleukin 1 (IL-1) gene cluster contains a major susceptibility locus for ankylosing spondylitis. Its polymorphisms are correlated with the susceptibility of ankylosing spondylitis. The study results are often different in different population. OBJECTIVE:To analyze the correlation between polymorphism of IL-1 receptor antagonist (IL-1RN) gene and patients with ankylosing spondylitis. The patients are the population of Han nationality of Hubei Province in China. METHODS:DNA samples were col ected from 140 patients with ankylosing spondylitis and 130 healthy as controls. The IL-1RN VNTR polymorphisms were determined by PCR method. Al patients are of Han nationality and lived in Hubei Province for three generations at least. RESULTS AND CONCLUSION:Compared with the healthy controls, IL-1RN VNTR*2 al elic frequency in patients with ankylosing spondylitis was significant higher (P<0.05).